TRP Channels in Drug Discovery [E-Book]: Volume I / edited by Arpad Szallasi, Tamás Bíró.
Bíró, Tamás.
Szallasi, Arpad.
Totowa, NJ : Humana Press, 2012
XI, 446 p. 39 illus., 13 illus. in color. digital.
Methods in pharmacology and toxicology
Full Text
Table of Contents:
  • Introduction to TRPs: A Quest for Novel Drug Targets
  • TRP-Mediated Cytoskeletal Reorganization: Implications for Disease and Drug Development
  • TRPA1 in Drug Discovery
  • Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases
  • TRPM2 Function and Potential as a Drug Target
  • The Ca2+-Activated Monovalent Cation Selective Channels TRPM4 and TRPM5
  • The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis
  • TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation
  • TRPML Channels in Function, Disease, and Prospective Therapies
  • The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1
  • TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities
  • Nociceptive and Non-Nociceptive Roles of TRPV3 and Its “Druggability”
  • TRPV4 and Drug Discovery
  • TRP Expression and Function in the Lung Airways
  • Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells
  • Endotoxin-Induced Airway Inflammation and Asthma Models
  • Enhanced Cough, Animal Models
  • Capsaicin Inhalation Test in Man
  • TRP Channels in the Genitourinary (GU) Tract
  • Animal Models of Cystitis
  • Overactive Bladder Models..