Target Identification and Validation in Drug Discovery [E-Book] : Methods and Protocols / edited by Jurgen Moll, Riccardo Colombo.
The major reason for the elevated costs of drug development in the pharmaceutical industry is the high attrition rate. In Target Identification and Validation in Drug Discovery: Methods and Protocols, expert researchers in the field detail many of the methods which are now commonly used to identify...
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Full text |
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Personal Name(s): | Colombo, Riccardo. |
Moll, Jurgen. | |
Imprint: |
Totowa, NJ :
Humana Press,
2013
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Physical Description: |
XV, 371 p. 62 illus., 19 illus. in color. digital. |
Note: |
englisch |
ISBN: |
9781627033114 |
DOI: |
10.1007/978-1-62703-311-4 |
Series Title: |
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Methods in molecular biology, methods and protocols ;
986 |
Subject (LOC): |
- The Path to Oncology Drug Target Validation – an Industry Perspective
- Identification of Aptamers as Specific Binders and Modulators of Cell-Surface Receptor Activity
- The Design and Structure-functional Properties of DNA-based Immunomodulatory Sequences
- siRNA Design Principles and Off-target Effects
- Western Blot Evaluation of siRNA Delivery by pH Responsive Peptides
- High Throughput RNAi Screening for the Identification of Novel Targets
- Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development
- CellProfiler and KNIME: Open Source Tools for High Content Screening
- PARP Inhibition as a Prototype for Synthetic Lethal Screens
- Structure-Based Target Druggability Assessment
- Validating Pharmacological Disruption of Protein-protein Interactions by Acceptor Photobleaching FRET Imaging
- Systematic Analysis of Complex Signal Transduction Pathways using Protein Fragment Complementation Assays
- Reverse-Phase Protein Microarrays and Their Utility in Drug Development
- A Cell Culture System that Mimics Chronic Lymphocytic Leukemia Cells Microenvironment for Drug Screening and Characterization
- 2-Dimensional vs. 3-Dimensional in vitro Tumor Migration and Invasion Assays
- Tumor Spheroid-based Migration Assays for Evaluation of Therapeutic Agents
- The NeuroSphere Assay (NSA) Applied to Neural Stem Cells (NSCs) and Cancer Stem Cells (CSCs).-Genetically Engineered Animal Models for in vivo Target Identification and Validation in Oncology
- Target Validation in Mice by Constitutive and Conditional RNAi
- In vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models
- Brightfield In Situ Hybridization Methods to Discover Gene Amplifications and Rearrangements in Clinical Samples
- Combined microRNA In Situ Hybridization and Immunohistochemical Detection of Protein Markers.