Genotoxicity Assessment [E-Book] : Methods and Protocols /

Genotoxicity Assessment [E-Book] : Methods and Protocols / edited by Alok Dhawan, Mahima Bajpayee.

Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols...

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Bajpayee, Mahima. editor
Dhawan, Alok. editor
Totowa, NJ : Humana Press, 2013
XV, 463 p. 106 illus., 62 illus. in color. online resource.
englisch
9781627035293
10.1007/978-1-62703-529-3
Methods in molecular biology, methods and protocols ; 1044
Human genetics.
Medicine.
Toxicology.



  • Bacterial Mutation Assays
  • In Vitro Mouse Lymphoma (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay
  • Erythrocyte
  • Based Pig
  • a Gene Mutation Assay
  • Detection of in vivo Mutation in the Hprt and Pig
  • a Genes of Rat Lymphocytes
  • In vivo cII, gpt, and Spi- gene Mutation Assays in Transgenic Mice and Rats
  • In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests
  • Analysis of Chromosome Aberrations in Somatic and Germ Cells of the Mouse
  • Chromosomal Aberration Test in Human Lymphocytes
  • In vivo Micronucleus Assay in Mouse Bone Marrow and Peripheral Blood
  • Micronucleus Assay in Human Cells: Lymphocytes and Buccal Cells
  • Flow Cytometric Determination of Micronucleus Frequency
  • Fluorescent in situ Hybridization (FISH) Technique for the Micronucleus Test
  • Comparative Genomic Hybridization (CGH) in Genotoxicology
  • The in vitro Micronucleus Assay and Kinetochore Staining: Methodology and Criteria for the Accurate Assessment of Genotoxicity and Cytotoxicity
  • g
  • H2AX Detection in Somatic and Germ Cells of Mice
  • Multicolour Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers
  • The Comet Assay: Assessment of in vitro and in vivo DNA Damage
  • The Comet Assay in Human Biomonitoring
  • The Comet assay in Marine Animals
  • Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo
  • 32P
  • Postlabeling Analysis of DNA Adducts
  • Micronucleus Assay with Tetrad Cells of Tradescantia
  • The Wing
  • Spot and the Comet Tests as useful Assays Detecting Genotoxicity in Drosophila
  • Genotoxicity Guidelines Recommended by International Conference of Harmonization (ICH).