High-Throughput Screening Assays in Toxicology [E-Book] / edited by Hao Zhu, Menghang Xia.
Xia, Menghang, (editor)
Zhu, Hao, (editor)
New York, NY : Humana Press, 2016
XII, 175 p. 50 illus., 32 illus. in color. online resource.
englisch
9781493963461
10.1007/978-1-4939-6346-1
Methods in molecular biology ; 1473
Full Text
Table of Contents:
  • Monitoring Ligand-Activated Protein-Protein Interactions Using Bioluminescent Resonance Energy Transfer (BRET) Assay
  • Mitochondrial Membrane Potential Assay
  • Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Signaling Pathway
  • Quantitative High-Throughput Luciferase Screening in Identifying CAR Modulators
  • Transactivation and Coactivator Recruitment Assays for Measuring Farnesoid X Receptor Activity
  • Cell-Based Assay for Identifying the Modulators of Antioxidant Response Element Signaling Pathway
  • Study Liver Cytochrome P450 3A4 Inhibition and Hepatotoxicity Using DMSO-Differentiated HuH-7 Cells
  • Determination of Histone H2AX Phosphorylation in DT40 Cells
  • High-Throughput and High Content Micronucleus Assay in CHO-K1 Cells
  • Better, Faster, Cheaper: Getting the Most Out of High-Throughput Screening with Zebrafish
  • Fast Functional Germline and Epigenetic Assays in the Nematode <Caenorhabditis elegans
  • A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling
  • Correction of Microplate Data from High-Throughput Screening
  • CurveP Method for Rendering High-Throughput Screening Dose-Response Data into Digital Fingerprints
  • Accounting Artifacts in High-Throughput Toxicity Assays
  • Accessing the High-Throughput Screening Data Landscape
  • Curating and Preparing High Throughput Screening Data for Quantitative Structure Activity Relationship Modeling.