Chemical warfare toxicology. [E-Book] / edited by Franz Worek, John Jenner, and Horst Thiermann. Volume 2, Management of poisoning
Worek, Franz, (editor)
Jenner, John, (editor) / Thiermann, Horst, (editor)
Cambridge, UK : Royal Society of Chemistry, 2016
1 online resource (xx, 325 pages).
Issues in toxicology ; 27
Full Text
Table of Contents:
  • Cover; Chemical Warfare Toxicology Volume 2: Management of Poisoning; Preface; References to Material in The National Archives; Contents; Chapter 1
  • Treatment of Nerve Agent Poisoning; 1.1 Introduction; 1.2 OP Compounds; 1.2.1 General Remarks That Are Relevant for Therapy; 1.2.2 Toxicology of OP Compounds; Toxicokinetic Aspects Relevant for Therapy; Toxicodynamics of Nerve Agents; Reactions of Nerve Agents with AChE.OP compounds, i.e. nerve agents and pesticides, inhibit serine esterases such as AChE (E.C. ...
  • Binding of Nerve Agents to Other Targets.As highly reactive compounds, nerve agents are able to interact with a variety of prote...1.3 Protective Measures and Decontamination; 1.4 Clinical Picture of Nerve Agent Poisoning; 1.4.1 Acute Nerve Agent Poisoning; Central Nervous System; Autonomic Nervous System; Sympathetic Nervous System.Nicotinic ACh receptors are located at paravertebral sympathetic ganglions. In response to the pregan...
  • Parasympathetic Nervous System.ACh is the primary neurotransmitter of the parasympathetic nervous system and neurotransmission o... Somatic Nervous System; Conclusion; 1.4.2 Intermediate Syndrome; 1.4.3 Organophosphate Induced Delayed Neuropathy; 1.5 Pretreatment; 1.6 Differences Between Nerve Agent and OP Compound Pesticide Poisoning; 1.7 Therapeutic Regimen of Nerve Agent Poisoning; 1.7.1 General Considerations; 1.7.2 Atropine; Self and Buddy Aid; Treatment by Medical Specialists; 1.7.3 Oximes; General Background
  • Effectiveness of Oximes in Nerve Agent Poisoning1.7.3.3 Interaction with Persisting Poison Load; Oxime Dosing Strategies; Monitoring of Oxime Therapy; Obidoxime; Pralidoxime; HI-6; Benzodiazepines; Magnesium; Alkalinization by Sodium Bicarbonate; Supportive Treatment; 1.8 Summary and Outlook; References; Chapter 2
  • Nerve Agents: Catalytic Scavengers as an Alternative Approach for Medical Countermeasures; 2.1 Introduction; 2.2 The Scavenger Concept; 2.3 Endogenous Bioscavengers; 2.4 Stoichiometric Scavengers
  • 2.5 Pseudo-Catalytic Scavengers2.6 Catalytic Scavengers; 2.7 Requirements for Operational Catalytic Scavengers; 2.8 Potential Enzymes; 2.8.1 Phosphotriesterases; Bacterial PTEs; Human Paraoxonase; Other Mammalian PTEs; 2.8.2 Engineered ChEs and CaEs; 2.8.3 Oxidases; Glutathione S-Transferases; Laccases; 2.9 Catalytic Antibodies; 2.10 Artificial Enzymes; 2.11 Future Directions; References; Chapter 3
  • Nicotinic Receptors as Targets for Nerve Agent Therapy; 3.1 Introduction; 3.2 Current Therapy for Nerve Agent Poisoning