Chemical warfare toxicology. [E-Book] / edited by Franz Worek, John Jenner, and Horst Thiermann. Volume 2, Management of poisoning
Worek, Franz, (editor)
Jenner, John, (editor) / Thiermann, Horst, (editor)
Cambridge, UK : Royal Society of Chemistry, 2016
1 online resource (xx, 325 pages).
englisch
9781782628071
9781523104772
178262807X
1523104775
Issues in toxicology ; 27
Full Text
Table of Contents:
  • Cover; Chemical Warfare Toxicology Volume 2: Management of Poisoning; Preface; References to Material in The National Archives; Contents; Chapter 1
  • Treatment of Nerve Agent Poisoning; 1.1 Introduction; 1.2 OP Compounds; 1.2.1 General Remarks That Are Relevant for Therapy; 1.2.2 Toxicology of OP Compounds; 1.2.2.1 Toxicokinetic Aspects Relevant for Therapy; 1.2.2.2 Toxicodynamics of Nerve Agents; 1.2.2.2.1 Reactions of Nerve Agents with AChE.OP compounds, i.e. nerve agents and pesticides, inhibit serine esterases such as AChE (E.C. ...
  • 1.2.2.2.2 Binding of Nerve Agents to Other Targets.As highly reactive compounds, nerve agents are able to interact with a variety of prote...1.3 Protective Measures and Decontamination; 1.4 Clinical Picture of Nerve Agent Poisoning; 1.4.1 Acute Nerve Agent Poisoning; 1.4.1.1 Central Nervous System; 1.4.1.2 Autonomic Nervous System; 1.4.1.2.1 Sympathetic Nervous System.Nicotinic ACh receptors are located at paravertebral sympathetic ganglions. In response to the pregan...
  • 1.4.1.2.2 Parasympathetic Nervous System.ACh is the primary neurotransmitter of the parasympathetic nervous system and neurotransmission o...1.4.1.3 Somatic Nervous System; 1.4.1.4 Conclusion; 1.4.2 Intermediate Syndrome; 1.4.3 Organophosphate Induced Delayed Neuropathy; 1.5 Pretreatment; 1.6 Differences Between Nerve Agent and OP Compound Pesticide Poisoning; 1.7 Therapeutic Regimen of Nerve Agent Poisoning; 1.7.1 General Considerations; 1.7.2 Atropine; 1.7.2.1 Self and Buddy Aid; 1.7.2.2 Treatment by Medical Specialists; 1.7.3 Oximes; 1.7.3.1 General Background
  • 1.7.3.2 Effectiveness of Oximes in Nerve Agent Poisoning1.7.3.3 Interaction with Persisting Poison Load; 1.7.3.4 Oxime Dosing Strategies; 1.7.3.5 Monitoring of Oxime Therapy; 1.7.3.6 Obidoxime; 1.7.3.7 Pralidoxime; 1.7.3.8 HI-6; 1.7.3.9 Benzodiazepines; 1.7.3.10 Magnesium; 1.7.3.11 Alkalinization by Sodium Bicarbonate; 1.7.3.12 Supportive Treatment; 1.8 Summary and Outlook; References; Chapter 2
  • Nerve Agents: Catalytic Scavengers as an Alternative Approach for Medical Countermeasures; 2.1 Introduction; 2.2 The Scavenger Concept; 2.3 Endogenous Bioscavengers; 2.4 Stoichiometric Scavengers
  • 2.5 Pseudo-Catalytic Scavengers2.6 Catalytic Scavengers; 2.7 Requirements for Operational Catalytic Scavengers; 2.8 Potential Enzymes; 2.8.1 Phosphotriesterases; 2.8.1.1 Bacterial PTEs; 2.8.1.2 Human Paraoxonase; 2.8.1.3 Other Mammalian PTEs; 2.8.2 Engineered ChEs and CaEs; 2.8.3 Oxidases; 2.8.3.1 Glutathione S-Transferases; 2.8.3.2 Laccases; 2.9 Catalytic Antibodies; 2.10 Artificial Enzymes; 2.11 Future Directions; References; Chapter 3
  • Nicotinic Receptors as Targets for Nerve Agent Therapy; 3.1 Introduction; 3.2 Current Therapy for Nerve Agent Poisoning