Alcohol and the nervous system [E-Book] / volume editors, Edith V. Sullican and Adolf Pfefferbaum.
Sullivan, Edith V., (editor)
Pfefferbaum, Adolf, (editor)
Edinburgh : Elsevier, 2014
1 online resource : illustrations.
Handbook of clinical neurology ; 125
Full Text
Table of Contents:
  • Front Cover; Alcohol and the Nervous System; Copyright; Handbook of Clinical Neurology 3rd Series; Foreword; Preface; Contributors; Contents; Section 1: Introduction; Chapter 1: Alcoholism: Diagnosis, Prognosis, Epidemiology, and Burden Of the Disease; Natural History and Clinical Assessment; Alcoholism Frequency; Practical Typology; Diagnosis; Alcohol Use History; Making a Diagnosis; Physiologic Dependence: Tolerance And withdrawal; Tolerance; Withdrawal; Loss of Control Phenomenon; Social Or Physical Decline; Gauging Prognosis; Positive Versus Negative; Diagnosis is Prognosis.
  • Abuse Rather than DependenceBehavioral Versus Hepatic Diagnosis; Assessing Ambivalence and Continuing Loss Of Control risk; Social Stability; Vaillant''s Four Prognostic Factors; Structured time; A Rehabilitation Relationship; Sources of Hope Or self-esteem; A Negative Behavioral Reinforcer; Summing Up Prognosis; Other Psychiatric Assessment; Dsm-5 and Alcoholism Diagnosis: Progress Or Old Wine in a New Bottle?; Economic Costs of Problematic Alcohol use; Cost of Illness: Clarifying the Concept; Cost: Contribution By Category; Interpretation: Cost Consequences; Economics and Alcohol.
  • Alcohol-related Spending and Other Disease CategoriesConclusion; References; Chapter 2: Perspectives on the Neuroscience of Alcohol From the National Institute on Alcohol Abuse and Alcoholism; Introduction; The Division of Neuroscience and Behavior (Dnb) and Its Mission; Genetics; Neuroadaptation; Behavior; Neurobehavioral, Structural, and Functional Consequences of Human Alcoholism; Preclinical Medications Development; Future Directions; References; Section 2: Animal Models: Neurochemistry and Metabolism of Alcohol; Chapter 3: Neurocircuitry of Alcohol Addiction: Synthesis From animal models.
  • Definitions and Conceptual Framework for Neurocircuitry of AlcoholismAnimal Models for Compulsive Alcohol Seeking; Animal Models of Motivation, Withdrawal, and Opponent Process; Neurocircuits for the Binge/intoxication Stage Associated With Alcoholism; Neural Substrates for the Withdrawal/negative Affect Stage Associated With Alcoholism; Within-system Neuroadaptations That Contribute to the Compulsivity Associated With the Dark Side of Alcoholism; Between-system Neuroadaptations That Contribute to Compulsivity Associated With the Dark Side of Alcoholism.
  • Neural Substrates for Executive Function Deficits Associated With alcoholismCompulsivity in Alcoholism: An allostatic view; Acknowledgments; References; Chapter 4: Metabolism; Overview; Ethanol Metabolism; Hepatic Ethanol Metabolism; Genetic Factors: Genetic Variants And gender; Genetic Variation in Adh, Aldh2, Cyp2E1 and Ethanol Metabolism; Genetic Predisposition to Alcoholism; Effects of Gender on Alcohol Metabolism; Fasting; Protein Malnutrition; Effect of Fat Content Or Composition Of diet; Effect of Dietary Ethanol; Miscellaneous Dietary Effects; Endocrine Effects.