Arrest chemokines [E-Book] / Klaus Ley
Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized o...
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Full text |
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Imprint: |
Lausanne :
Frontiers Media SA,
2015
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Physical Description: |
1 electronic resource (108 pages) |
Note: |
englisch |
ISBN: |
9782889194308 |
Keywords: |
chemokine ; leukocyte adhesion ; integrin ; Talin ; Kindlin-3 ; LFA-1 ; VLA-4 ; Signal Transduction |
Subject (LOC): |
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520 | |a Arrest chemokines are a small group of chemokines that promote leukocyte arrest from rolling by triggering rapid integrin activation. Arrest chemokines have been described for neutrophils, monocytes, eosinophils, naïve lymphocytes and effector memory T cells. Most arrest chemokines are immobilized on the endothelial surface by binding to heparin sulfate proteoglycans. Whether soluble chemokines can promote integrin activation and arrest is controversial (Alon-Gerszten). Many aspects of the signaling pathway from the GPCR chemokine receptor to integrin activation are the subject of active investigation. Leukocyte adhesion deficiency III is a human disease in which chemokine-triggered integrin activation is defective because of a mutation in the cytoskeletal protein kindlin-3. About 10 different such mutations have been described. The defects seen in patients with LAD-III elucidate the importance of rapid integrin activation for host defense in humans. We welcome reports that help clarifying this crucial first step in the process of leukocyte transendothelial migration. | ||
650 | 0 | |a Immunologic diseases. Allergy | |
650 | 0 | |a Medicine (General) | |
653 | |a chemokine ; leukocyte adhesion ; integrin ; Talin ; Kindlin-3 ; LFA-1 ; VLA-4 ; Signal Transduction | ||
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