Preclinical and clinical issues in Alzheimer's disease drug research and development [E-Book] / Silvana Gaetani ; Cesare Mancuso
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by b...
Saved in:
|
Full text |
|
| Imprint: |
Lausanne :
Frontiers Media SA,
2015
|
| Physical Description: |
1 electronic resource (100 pages) |
| Note: |
englisch |
| ISBN: |
9782889194339 |
| Keywords: |
Alzheimer's disease ; preclinical studies ; Clinical Trials as Topic ; drug research and development ; neurodegeneration |
| Subject (LOC): |
| LEADER | 03512nam a2200277uu 4500 | ||
|---|---|---|---|
| 001 | 18188 | ||
| 008 | 170415s|||| xx o 0 u ||| | | ||
| 020 | |a 9782889194339 | ||
| 035 | |a (Sirsi) a660777 | ||
| 035 | |a a660777 | ||
| 041 | |a eng | ||
| 245 | 1 | 0 | |a Preclinical and clinical issues in Alzheimer's disease drug research and development |h [E-Book] / |c Silvana Gaetani ; Cesare Mancuso |
| 264 | 1 | |a Lausanne : |b Frontiers Media SA, |c 2015 |e (DOAB) | |
| 300 | |a 1 electronic resource (100 pages) | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a englisch | ||
| 520 | |a Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called “amyloid cascade hypothesis”, amyloid-ß- peptide (Aß), produced by beta- and gamma- secretase-mediated cleavages of the amyloid precursor protein (APP), plays a pivotal role in the pathogenesis of AD. Aß was also shown to contribute to AD pathology by stimulating the hyperphosphorylation of tau which is responsible for the formation of neurofibrillary tangles. However, the “amyloid cascade hypothesis” was challenged by other theories which lend support to the idea that Aß is not causative but can be considered as an “innocent bystander” in AD. Although preclinical research generated impressive lines of evidence about the several intracellular mechanism(s) whose impairment leads to the onset and progression of AD, clinical research aimed at the development of new drugs capable of preventing or delaying the onset of neuronal damage in AD patients has produced limited results. The drugs currently available for the treatment of AD are acetylcholinesterase inhibitors (AChEI) and the NMDA glutamate receptor antagonist memantine. The AChEI increase acetylcholine levels in the synaptic cleft, which are reduced because of the progressive damage of cholinergic neurons in cognitive brain areas (e.g. amygdala, hippocampus, and frontal cortex), whereas memantine is used to prevent/reduce calcium-dependent excitotoxic neuronal cell death. Both classes of drugs have been shown to improve symptoms related to cognitive decline, but their effects are confined largely to patients with mild to moderate AD, in particular during the first year or so of treatment. An alternative to this symptomatic treatments involves the use of drugs that intervene in the pathogenesis of the disease. Recently, monoclonal antibodies against Aß were proposed as novel agents capable to remove Aß from the brain thus preventing neuronal damage. The research topic focuses on the preclinical and clinical evidence about the several factors that contribute to the pathogenesis of AD as well as the potential therapeutic role of new classes of drugs still under preclinical or clinical development. | ||
| 650 | 0 | |a Therapeutics. Pharmacology | |
| 650 | 0 | |a Science (General) | |
| 653 | |a Alzheimer's disease ; preclinical studies ; Clinical Trials as Topic ; drug research and development ; neurodegeneration | ||
| 856 | |u http://journal.frontiersin.org/researchtopic/1668/preclinical-and-clinical-issues-in-alzheimers-disease-drug-research-and-development |z Volltext | ||
| 915 | |a zzwFZJFrontiers | ||
| 596 | |a 1 | ||
| 949 | |a XX(660777.1) |w AUTO |c 1 |i 660777-1001 |l ELECTRONIC |m ZB |r N |s Y |t E-BOOK |u 15/5/2017 |x UNKNOWN |z UNKNOWN |1 ONLINE | ||