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Chromothripsis [E-Book] : Methods and Protocols / edited by Franck Pellestor.

This detailed book presents an up-to-date view on methods and experimental approaches developed to identify and explore the chromothripsis phenomenon. Beginning with a section exploring the genesis and impact of chromothripsis, the collection continues by covering the identification of chromothripsi...

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Personal Name(s): Pellestor, Franck, editor
Imprint: New York, NY : Humana Press, 2018
Physical Description: XI, 367 p. 85 illus., 73 illus. in color. online resource.
Note: englisch
ISBN: 9781493977802
DOI: 10.1007/978-1-4939-7780-2
Series Title: Methods in molecular biology ; 1769
Subject (ZB):
chromosome
genome analysis
molecular genetics
sequence analysis
Subject (LOC):
Human genetics.
Medicine.
Classification:
LOH - Genetics - methods
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  • Description
  • Table of Contents
  • Staff View

  • The Genomic Characteristics and Origin of Chromothripsis
  • Clinical Consequences of Chromothripsis and Other Catastrophic Cellular Events
  • Potential Role of Chromothripsis in the Genesis of Complex Chromosomal Rearrangements in Human Gametes and Preimplantation Embryo
  • Chromothripsis and the Macroevolution Theory
  • Analysis of Chromothripsis by Combined FISH and Microarray Analysis
  • Chromothripsis Detectable in Small Supernumerary Marker Chromosomes (sSMC) Using Fluorescence In Situ Hybridization (FISH)
  • Identification of Chromothripsis in Biopsy Using SNP-Based Microarray
  • Detection of Chromothripsis in Plants
  • RNA-Seq Analysis to Detect Abnormal Fusion Transcripts Linked to Chromothripsis
  • Experimental Determination of Checkpoint Adaptation by Mitotic Shake-Off and Microscopy
  • A Role for Retrotransposons in Chromothripsis
  • Generation of Micronuclei and Detection of Chromosome Pulverization
  • Detection of Impaired DNA Replication and Repair in Micronuclei as Indicators of Genomic Instability and Chromothripsis
  • Study of Telomere Dysfunction in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
  • Genes, Proteins, and Biological Pathways Preventing Chromothripsis
  • Expression of Genes Associated with Telomere Homeostasis in TP53 Mutant LoVo Cell Lines as a Model for Genomic Instability
  • Chromothripsis Detection and Characterization Using the CTLPScanner Web Server
  • ChromothripsisDB: A Curated Database for the Documentation, Visualization, and Mining of Chromothripsis Data
  • Time-Lapse Imaging for the Detection of Chromosomal Abnormalities in Primate Pre-Implantation Embryos
  • Correlative Live Imaging and Immunofluorescence for Analysis of Chromosome Segregation in Mouse Preimplantation Embryos
  • Experimental Induction of Genome Chaos
  • Looking for Broken TAD Boundaries and Changes on DNA Interactions: Clinical Guide to 3D Chromatin Changes Analysis in Complex Chromosomal Rearrangements and Chromothripsis.

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