Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane [E-Book] / by Ksenia Guseva.
With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It...
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Personal Name(s): | Guseva, Ksenia, author |
Edition: |
1st ed. 2012. |
Imprint: |
Berlin, Heidelberg :
Springer,
2012
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Physical Description: |
XII, 80 pages (online resource) |
Note: |
englisch |
ISBN: |
9783642239885 |
DOI: |
10.1007/978-3-642-23988-5 |
Series Title: |
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Springer Theses, Recognizing Outstanding Ph.D. Research
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Subject (LOC): |
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245 | 1 | 0 | |a Formation and Cooperative Behaviour of Protein Complexes on the Cell Membrane |h [E-Book] / |c by Ksenia Guseva. |
250 | |a 1st ed. 2012. | ||
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300 | |a XII, 80 pages (online resource) | ||
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500 | |a englisch | ||
505 | 0 | |a Introduction -- The Role of Fragmentation on the Formation of Homomeric Protein Complexes -- Collective Response of Self-organised Clusters of Mechanosensitive Channels -- Assembly and Fragmentation of Tat Pores -- Conclusion. | |
520 | |a With the aim of providing a deeper insight into possible mechanisms of biological self-organization, this thesis presents new approaches to describe the process of self-assembly and the impact of spatial organization on the function of membrane proteins, from a statistical physics point of view. It focuses on three important scenarios: the assembly of membrane proteins, the collective response of mechanosensitive channels and the function of the twin arginine translocation (Tat) system. Using methods from equilibrium and non-equilibrium statistical mechanics, general conclusions were drawn that demonstrate the importance of the protein-protein interactions. Namely, in the first part a general aggregation dynamics model is formulated, and used to show that fragmentation crucially affects the efficiency of the self-assembly process of proteins. In the second part, by mapping the membrane-mediated forces into a simplified many-body system, the dynamic and equilibrium behaviour of interacting mechanosensitive channels is derived, showing that protein agglomeration strongly impacts its desired function. The final part develops a model that incorporates both the agglomeration and transport function of the Tat system, thereby providing a comprehensive description of this self-organizing process. | ||
650 | 0 | |a Cell membranes. | |
650 | 0 | |a Polymers. | |
650 | 0 | |a Statistical physics. | |
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