Behavioral genetics of the mouse. [E-Book] / edited by Susanna Pietropaolo, Frans Sluyter, Wim E. Crusio. Volume 2, Genetic mouse models of neurobehavioral disorders
Pietropaolo, Susanna, (editor)
Sluyter, Frans, (editor) / Crusio, W. E., (editor)
Cambridge : Cambridge University Press, 2014
1 online resource (xii, 457 pages)
Cambridge handbooks in behavioural genetics
Full Text
The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders; from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.