Molecular Medicine [E-Book] : How Science Works /

Molecular Medicine [E-Book] : How Science Works / by Carsten Carlberg, Eunike Velleuer, Ferdinand Molnár.

The fascinating area of molecular medicine provides a molecular and cellular description of health and disease. Starting with the understanding of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin, this book will provide an fundamental basis of nearly all pr...

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Carlberg, Carsten, author
Molnár, Ferdinand, author / Velleuer, Eunike, author
1st edition 2023.
Cham : Springer, 2023
XXXIV, 700 pages 301 illustrations, 300 illustrations in color (online resource)
englisch
9783031271335
10.1007/978-3-031-27133-5
Biology -- Research.
Cancer.
Genomics.
Immunology.
Medicine -- Research.
Nutrition   .
Physiology.



  • 1. The human genome and its variations
  • 2. Gene expression and chromatin
  • 3. The basal transcriptional machinery
  • 4. Transcription factors and signal transduction
  • 5. A key transcription factor family: Nuclear receptors
  • 6. DNA methylation
  • 7. Histone modifications
  • 8. Chromatin remodeling and organization
  • 9. Regulatory impact of non-coding RNA
  • 10. Genome-wide principles of gene regulation
  • 11. Epigenetics in development
  • 12. Epigenetics and aging
  • 13. Epigenetics and disease
  • 14. Cells and tissues of the immune system
  • 15. Innate immunity and inflammation
  • 16. Adaptive immunity and antigen receptor diversity
  • 17. B cell immunity: BCRs, antibodies and their effector functions
  • 18. Antigen-presenting cells and MHCs
  • 19. T cell immunity: TCRs and their effector functions
  • 20. Immunity to bacterial pathogens and the microbiome
  • 21. Immunity to viral pathogens and the virome
  • 22. Tolerance and transplantation immunology
  • 23. Immunological hypersensitivities: Allergy and autoimmunity
  • 24. Introduction to cancer
  • 25. Oncogenes, signal transduction and the hallmarks of cancer
  • 26 Tumor suppressor genes and cell fate control
  • 27. Multistep tumorigenesis and genome instability
  • 28. Cancer genomics
  • 29. Cancer epigenomics.-30. Aging and cancer
  • 31. Tumor microenvironment
  • 32 Metastasis and cachexia
  • 33. Cancer immunology
  • 34 Architecture of cancer therapies
  • 35 Nutrition and common diseases
  • 36 Interference of the human genome with nutrients
  • 37. Nutritional epigenetics, signaling and aging
  • 38. Chronic inflammation and metabolic stress
  • 39. Obesity
  • 40. Insulin resistance and diabetes
  • 41. Heart disease and the metabolic syndrome
  • 42 Epigenetics, inflammation and disease.