Description: Differential activation of memory-relevant brain regions during a dialysis cycle

This title appears in the Scientific Report : 2010

Differential activation of memory-relevant brain regions during a dialysis cycle

Cognitive impairment is a common and largely undiagnosed finding in a significant number of dialysis patients. These alterations may result from concomitant cerebrovascular disease, hemodynamic instability, the uremic milieu, or changes induced by the dialysis process. In order to gain further insig...

Personal Name(s):	Lux, S.
	Mirzazade, S. / Kuzmanovic, B. / Plewan, T. / Eickhoff, S. B. / Shah, J. N. / Floege, J. / Fink, G. R. / Eitner, F.
Contributing Institute:	Physik der Medizinischen Bildgebung; INM-4 Kognitive Neurowissenschaften; INM-3 Molekulare Organisation des Gehirns; INM-2 Strukturelle und funktionelle Organisation des Gehirns; INM-1 JARA-BRAIN; JARA-BRAIN
Published in:	Kidney international / Supplements, 78 (2010) S. 794 - 802
Imprint:	[S.l.] Wiley-Blackwell 2010
Physical Description:	794 - 802
PubMed ID:	20668428
DOI:	10.1038/ki.2010.253
Document Type:	Journal Article
Research Program:	(Dys-)function and Plasticity Funktion und Dysfunktion des Nervensystems
Series Title:	Kidney International 78
Subject (ZB):	Adult Brain Mapping Case-Control Studies Cognition Disorders: etiology Female Hippocampus: physiopathology Humans Magnetic Resonance Imaging Male Memory: physiology Middle Aged Neuropsychological Tests Prospective Studies Renal Dialysis: adverse effects Verbal Learning Young Adult J dementia dialysis volume end-stage renal disease uremia
	Publikationsportal JuSER

Please use the identifier: http://dx.doi.org/10.1038/ki.2010.253 in citations.

Cognitive impairment is a common and largely undiagnosed finding in a significant number of dialysis patients. These alterations may result from concomitant cerebrovascular disease, hemodynamic instability, the uremic milieu, or changes induced by the dialysis process. In order to gain further insight into this, we recruited 12 stable chronic hemodialysis patients (without clinical neurological disease) and an age- and gender-matched cohort of 12 control individuals (without renal or neurological problems) in a prospective, single-center study. In order to disentangle the influence of dialysis itself on memory function, each dialysis patient was tested twice: once immediately before dialysis following a long weekend (t1) and again the day after this dialysis (t2). The control individuals were tested in the same time frame. Neuropsychological testing found that the control individuals performed significantly better in verbal learning, motor speed, task switching, verbal comprehension, word fluency, spatial visualization, spatial perception, and reasoning; all independent of the time point. Functional magnetic resonance imaging of the whole brain in seven hemodialysis patients found significantly more bilateral activation of the hippocampus during the verbal working memory task at t2 relative to t1 compared with their seven matched control counterparts. Thus, our study found differential and task-specific activation of memory-relevant brain areas during a dialysis cycle.