This title appears in the Scientific Report :
2010
Please use the identifier:
http://dx.doi.org/10.1007/s00415-010-5597-1 in citations.
Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson's disease
Theta burst stimulation over the primary motor cortex does not induce cortical plasticity in Parkinson's disease
The purpose of this study was to investigate whether a period of continuous theta burst stimulation (cTBS) induces cortical plasticity and thus improves bradykinesia of the upper limb in Parkinson's disease. In eight patients with Parkinson's disease (two females; mean age: 68.5 ± 5 years;...
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Personal Name(s): | Egger, C. |
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Fink, G. R. / Nowak, D. A. | |
Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 |
Published in: | Journal of Neurology, 257 (2010) S. 1669 - 1674 |
Imprint: |
[Darmstadt]
Steinkopf
2010
|
Physical Description: |
1669 - 1674 |
PubMed ID: |
20496035 |
DOI: |
10.1007/s00415-010-5597-1 |
Document Type: |
Journal Article |
Research Program: |
(Dys-)function and Plasticity Funktion und Dysfunktion des Nervensystems |
Series Title: |
Journal of Neurology
257 |
Subject (ZB): | |
Publikationsportal JuSER |
The purpose of this study was to investigate whether a period of continuous theta burst stimulation (cTBS) induces cortical plasticity and thus improves bradykinesia of the upper limb in Parkinson's disease. In eight patients with Parkinson's disease (two females; mean age: 68.5 ± 5 years; disease duration: 4 ± 3 years) electrophysiological (motor evoked potentials, contralateral and ipsilateral silent period) and behavioural (Purdue pegboard test, UPDRS motor subscore) parameters were evaluated before (baseline condition) and after a 40-s period of (1) real or (2) sham continuous theta burst stimulation over the primary motor cortex contralateral to the more affected body side off dopaminergic drugs. Compared to baseline, cTBS did change neither measures of cortical excitability nor behavioural measures. cTBS over the primary motor cortex does not impact on cortical excitability or motor function of the upper limb in Parkinson's disease. We interpret these data to reflect impaired cortical plasticity in Parkinson's disease. This study is an important contribution to the knowledge about impaired plasticity in Parkinson's disease. |