This title appears in the Scientific Report :
2010
Please use the identifier:
http://dx.doi.org/10.1007/s11099-010-0079-3 in citations.
Leaf development, gas exchange characteristics, and photorespiratory activity in maize seedlings
Leaf development, gas exchange characteristics, and photorespiratory activity in maize seedlings
Apoptotic cells were quantitated by light microscopy in a series of 288 breast carcinomas, and their number (cells/mm2 of neoplastic epithelium, i.e., the apoptotic index, AI) was related to various histopathological features and disease outcome. High AI was associated with tumour necrosis (P = 0.00...
Saved in:
Personal Name(s): | Kutschera, U. |
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Pieruschka, R. / Berry, J.A. | |
Contributing Institute: |
Pflanzenwissenschaften; IBG-2 |
Published in: | Photosynthetica, 48 (2010) S. 617 - 622 |
Imprint: |
Dordrecht [u.a.]
Springer Science + Business Media B.V
2010
|
Physical Description: |
617 - 622 |
DOI: |
10.1007/s11099-010-0079-3 |
PubMed ID: |
7857705 |
Document Type: |
Journal Article |
Research Program: |
Terrestrische Umwelt |
Series Title: |
Photosynthetica
48 |
Subject (ZB): | |
Publikationsportal JuSER |
Apoptotic cells were quantitated by light microscopy in a series of 288 breast carcinomas, and their number (cells/mm2 of neoplastic epithelium, i.e., the apoptotic index, AI) was related to various histopathological features and disease outcome. High AI was associated with tumour necrosis (P = 0.003), lack of tubule formation (P = 0.03), dense stromal lymphocyte infiltration (P = 0.0009), high grade of the tumour (P < 0.0001), DNA aneuploidy (P = 0.049), high S-phase fraction (P = 0.010), high mitotic rate (P < 0.0001), lack of sex steroid receptors (P = 0.004), expression of p53 tumour suppressor gene (P = 0.004), and high values of morphometrically measured nuclear factors (P < 0.05). In survival analysis, an AI greater than 3/mm2 was related to short recurrence-free survival in the entire cohort (P = 0.0079) as well as in the axillary lymph node-negative tumours (P = 0.0253). Survival of the patients with node-negative tumours (P = 0.0356), node-positive tumours (P = 0.0085) and in the entire cohort (P = 0.004) was related to AI. Recurrence-free survival was related to the mitotic index (P = 0.0012), ductal type (P = 0.011), S.D. of the nuclear area (P = 0.075), and axillary lymph node status (P = 0.096). Cox's analysis showed that only the tumour diameter (P < 0.001), axillary lymph node status (P = 0.001), progesterone receptor content (P = 0.004) and ductal type (P = 0.041) had independent prognostic value, whereas AI did not. |