This title appears in the Scientific Report :
2013
Modeling Extracellular Spikes and Local Field PotentialsRecorded in MEAs
Modeling Extracellular Spikes and Local Field PotentialsRecorded in MEAs
Multielectrode array (MEA) measurements of neuronal activity in brain slice preparations have become an important research tool. However, to take full advantage of this technology, accurate and reliable tools for quantitative modeling and analysis of the recorded data are required. In particular, th...
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Personal Name(s): | Ness, Torbjørn B (Corresponding author) |
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Hagen, Espen / Negwer, Moritz / Bakker, Rembrandt / Schubert, Dirk / Einevoll, Gaute T. | |
Contributing Institute: |
Computational and Systems Neuroscience; INM-6 |
Imprint: |
2012
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Conference: | 8th International Meeting on Substrate-Integrated Microelectrode Arrays, Reutlingen (Germany), 2012-07-10 - 2012-07-13 |
Document Type: |
Poster |
Research Program: |
Signalling Pathways and Mechanisms in the Nervous System |
Publikationsportal JuSER |
Multielectrode array (MEA) measurements of neuronal activity in brain slice preparations have become an important research tool. However, to take full advantage of this technology, accurate and reliable tools for quantitative modeling and analysis of the recorded data are required. In particular, the ’measurement physics’, i.e., the link between the potentials recorded at the electrode contacts and the underlying neural activity, must be properly established. We here present and demonstrate the use of a biophysical modeling scheme based on the Finite Element Method (FEM), addressing this issue. The power of modern computers, combined with the recent establishment of freely accessible databases containing hundreds of reconstructed neuronal dendritic morphologies now places such modeling within reach for all scientists in the field. |