This title appears in the Scientific Report :
2012
Please use the identifier:
http://hdl.handle.net/2128/4999 in citations.
Please use the identifier: http://dx.doi.org/10.3389/fpls.2012.00294 in citations.
Reverse Engineering: A Key Component of Systems Biology to Unravel Global Abiotic Stress Cross-Talk
Reverse Engineering: A Key Component of Systems Biology to Unravel Global Abiotic Stress Cross-Talk
Understanding the global abiotic stress response is an important stepping stone for the development of universal stress tolerance in plants in the era of climate change. Although co-occurrence of several stress factors (abiotic and biotic) in nature is found to be frequent, current attempts are poor...
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Personal Name(s): | Friedel, Swetlana (Corresponding author) |
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Usadel, Björn / von Wirén, Nicolaus / Sreenivasulu, Nese | |
Contributing Institute: |
Pflanzenwissenschaften; IBG-2 |
Published in: | Frontiers in Plant Physiology, 3 294, S. 1-16 |
Imprint: |
Lausanne
Frontiers Media83580
2012
|
DOI: |
10.3389/fpls.2012.00294 |
PubMed ID: |
23293646 |
Document Type: |
Journal Article |
Research Program: |
Sustainable Bioproduction |
Link: |
OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://dx.doi.org/10.3389/fpls.2012.00294 in citations.
Understanding the global abiotic stress response is an important stepping stone for the development of universal stress tolerance in plants in the era of climate change. Although co-occurrence of several stress factors (abiotic and biotic) in nature is found to be frequent, current attempts are poor to understand the complex physiological processes impacting plant growth under combinatory factors. In this review article, we discuss the recent advances of reverse engineering approaches that led to seminal discoveries of key candidate regulatory genes involved in cross-talk of abiotic stress responses and summarized the available tools of reverse engineering and its relevant application. Among the universally induced regulators involved in various abiotic stress responses, we highlight the importance of (i) abscisic acid (ABA) and jasmonic acid (JA) hormonal cross-talks and (ii) the central role of WRKY transcription factors (TF), potentially mediating both abiotic and biotic stress responses. Such interactome networks help not only to derive hypotheses but also play a vital role in identifying key regulatory targets and interconnected hormonal responses. To explore the full potential of gene network inference in the area of abiotic stress tolerance, we need to validate hypotheses by implementing time-dependent gene expression data from genetically engineered plants with modulated expression of target genes. We further propose to combine information on gene-by-gene interactions with data from physical interaction platforms such as protein–protein or TF-gene networks. |