This title appears in the Scientific Report : 2011 

Electrochemistry-mass spectrometry for mechanistic studies and simulation of oxidation processes in the environment
Hoffmann, Th.
Hofmann, D. / Klumpp, E. / Küppers, S.
Zentralabteilung für Chemische Analysen; ZCH
Agrosphäre; IBG-3
Analytical and bioanalytical chemistry, 399 (2011) S. 1859 - 1868
Berlin Springer 2011
1859 - 1868
10.1007/s00216-010-4575-x
21170519
Journal Article
Terrestrische Umwelt
Analytical and Bioanalytical Chemistry 399
J
Please use the identifier: http://dx.doi.org/10.1007/s00216-010-4575-x in citations.
Electrochemistry (EC) coupled to mass spectrometry (MS) has already been successfully applied to metabolism research for pharmaceutical applications, especially for the oxidation behaviour of drug substances. Xenobiotics (chemicals in the environment) also undergo various conversions; some of which are oxidative reactions. Therefore, EC-MS might be a suitable tool for the investigation of oxidative behaviour of xenobiotics. A further evaluation of this approach to environmental research is presented in the present paper using sulfonamide antibiotics. The results with sulfadiazine showed that EC-MS is a powerful tool for the elucidation of the oxidative degradation mechanism within a short time period. In addition, it was demonstrated that EC-MS can be used as a fast and easy method to model the chemical binding of xenobiotics to soil. The reaction of sulfadiazine with catechol, as a model substance for organic matter in soil, led to the expected chemical structure. Finally, by using EC-MS a first indication was obtained of the persistence of a component under chemical oxidation conditions for the comparison of the oxidative stability of different classes of xenobiotics. Overall, using just a few examples, the study demonstrates that EC-MS can be applied as a versatile tool for mechanistic studies of oxidative degradation pathways of xenobiotics and their possible interaction with soil organic matter as well as their oxidative stability in the environment. Further studies are needed to evaluate the full range of possibilities of the application of EC-MS in environmental research.