This title appears in the Scientific Report :
2011
Please use the identifier:
http://dx.doi.org/10.1007/s00216-010-4575-x in citations.
Electrochemistry-mass spectrometry for mechanistic studies and simulation of oxidation processes in the environment
Electrochemistry-mass spectrometry for mechanistic studies and simulation of oxidation processes in the environment
Electrochemistry (EC) coupled to mass spectrometry (MS) has already been successfully applied to metabolism research for pharmaceutical applications, especially for the oxidation behaviour of drug substances. Xenobiotics (chemicals in the environment) also undergo various conversions; some of which...
Saved in:
Personal Name(s): | Hoffmann, Th. |
---|---|
Hofmann, D. / Klumpp, E. / Küppers, S. | |
Contributing Institute: |
Zentralabteilung für Chemische Analysen; ZCH Agrosphäre; IBG-3 |
Published in: | Analytical and bioanalytical chemistry, 399 (2011) S. 1859 - 1868 |
Imprint: |
Berlin
Springer
2011
|
Physical Description: |
1859 - 1868 |
DOI: |
10.1007/s00216-010-4575-x |
PubMed ID: |
21170519 |
Document Type: |
Journal Article |
Research Program: |
Terrestrische Umwelt |
Series Title: |
Analytical and Bioanalytical Chemistry
399 |
Subject (ZB): | |
Publikationsportal JuSER |
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245 | |a Electrochemistry-mass spectrometry for mechanistic studies and simulation of oxidation processes in the environment | ||
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520 | |a Electrochemistry (EC) coupled to mass spectrometry (MS) has already been successfully applied to metabolism research for pharmaceutical applications, especially for the oxidation behaviour of drug substances. Xenobiotics (chemicals in the environment) also undergo various conversions; some of which are oxidative reactions. Therefore, EC-MS might be a suitable tool for the investigation of oxidative behaviour of xenobiotics. A further evaluation of this approach to environmental research is presented in the present paper using sulfonamide antibiotics. The results with sulfadiazine showed that EC-MS is a powerful tool for the elucidation of the oxidative degradation mechanism within a short time period. In addition, it was demonstrated that EC-MS can be used as a fast and easy method to model the chemical binding of xenobiotics to soil. The reaction of sulfadiazine with catechol, as a model substance for organic matter in soil, led to the expected chemical structure. Finally, by using EC-MS a first indication was obtained of the persistence of a component under chemical oxidation conditions for the comparison of the oxidative stability of different classes of xenobiotics. Overall, using just a few examples, the study demonstrates that EC-MS can be applied as a versatile tool for mechanistic studies of oxidative degradation pathways of xenobiotics and their possible interaction with soil organic matter as well as their oxidative stability in the environment. Further studies are needed to evaluate the full range of possibilities of the application of EC-MS in environmental research. | ||
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650 | 2 | |2 MeSH |a Electrochemistry | |
650 | 2 | |2 MeSH |a Mass Spectrometry | |
650 | 2 | |2 MeSH |a Oxidation-Reduction | |
650 | 2 | |2 MeSH |a Soil Pollutants: chemistry | |
650 | 2 | |2 MeSH |a Xenobiotics: chemistry | |
650 | 7 | |0 0 |2 NLM Chemicals |a Soil Pollutants | |
650 | 7 | |0 0 |2 NLM Chemicals |a Xenobiotics | |
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653 | 2 | 0 | |2 Author |a Degradation |
653 | 2 | 0 | |2 Author |a Xenobiotics |
653 | 2 | 0 | |2 Author |a Environment |
653 | 2 | 0 | |2 Author |a Electrochemistry |
653 | 2 | 0 | |2 Author |a Mass spectrometry |
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