This title appears in the Scientific Report :
2014
Please use the identifier:
http://dx.doi.org/10.1038/mp.2012.196 in citations.
Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction.
Deep brain stimulation of the nucleus accumbens and its usefulness in severe opioid addiction.
eep brain stimulation (DBS) of the nucleus accumbens (NAcc) has been recently reported to modulate substance-induced dysfunction and to promote an alteration of addictive behavior.1, 2, 3, 4 Here, we describe DBS-induced sustained heroin abstinence in two therapy-resistant opioid addicted patients t...
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Personal Name(s): | Kuhn, J (Corresponding author) |
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Möller, M / Treppmann, J F / Bartsch, C / Lenartz, D / Gruendler, T O J / Maarouf, M / Brosig, A / Barnikol, U B / Klosterkötter, J / Sturm, V | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | Molecular psychiatry, 19 (2014) S. 145-146 |
Imprint: |
London
Macmillan
2014
|
DOI: |
10.1038/mp.2012.196 |
PubMed ID: |
23337942 |
Document Type: |
Journal Article |
Research Program: |
Pathophysiological Mechanisms of Neurological and Psychiatric Diseases |
Publikationsportal JuSER |
eep brain stimulation (DBS) of the nucleus accumbens (NAcc) has been recently reported to modulate substance-induced dysfunction and to promote an alteration of addictive behavior.1, 2, 3, 4 Here, we describe DBS-induced sustained heroin abstinence in two therapy-resistant opioid addicted patients treated during the piloting phase to our clinical trial NCT01245075. Inclusion was based on (1) longtime heroin addiction according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) (2) at least one detoxification (here: up to 20 detoxifications) without a prolonged phase of abstinence and (3) longtime opiate replacement therapy with a constant dose of levomethadone (Ethics approval has been obtained for both pilot testing and clinical trial. |