This title appears in the Scientific Report :
2007
Please use the identifier:
http://dx.doi.org/10.1016/j.biosystems.2006.04.015 in citations.
Therapeutic rewiring by means of desynchronizing brain stimulation
Therapeutic rewiring by means of desynchronizing brain stimulation
We study possible anti-kindling effects of the standard high-frequency deep brain stimulation (HFDBS) and of a desynchronizing multisite coordinated reset stimulation (MCRS) theoretically in a mathematical model of the subthalamic nucleus (STN). The latter is an effective target for deep brain stimu...
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Personal Name(s): | Tass, P. A. |
---|---|
Hauptmann, C. | |
Contributing Institute: |
Gehirn & Verhalten; INM-7 |
Published in: | Biosystems, 89 (2007) 1-3, S. 173–181 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2007
|
DOI: |
10.1016/j.biosystems.2006.04.015 |
PubMed ID: |
17184901 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Biosystems
89 |
Subject (ZB): | |
Publikationsportal JuSER |
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520 | |a We study possible anti-kindling effects of the standard high-frequency deep brain stimulation (HFDBS) and of a desynchronizing multisite coordinated reset stimulation (MCRS) theoretically in a mathematical model of the subthalamic nucleus (STN). The latter is an effective target for deep brain stimulation (DBS) in patients suffering from Parkinson's disease (PD). Depending on the structures being activated, electrical pulses may have excitatory and/or inhibitory impact. According to our simulation results MCRS may achieve robust long-term anti-kindling (i.e., curative) effects, irrespectively, of the ratio between excitatory and inhibitory impact. This means, that during MCRS the STN unlearns its pathologic synaptic connections and reestablishes a physiological level of connectivity. In contrast, HFDBS has anti-kindling effects only if its impact is predominantly excitatory. Our results are relevant for selecting appropriate locations for DBS electrodes. In fact, even with HFDBS we may expect anti-kindling effects, provided the target is properly chosen. | ||
653 | 2 | 0 | |2 Author |a plasticity |
653 | 2 | 0 | |2 Author |a therapeutic rewiring |
653 | 2 | 0 | |2 Author |a desynchronization |
653 | 2 | 0 | |2 Author |a deep brain stimulation |
650 | 2 | |2 MeSH |a Brain: physiopathology | |
650 | 2 | |2 MeSH |a Deep Brain Stimulation | |
650 | 2 | |2 MeSH |a Humans | |
650 | 2 | |2 MeSH |a Neuronal Plasticity | |
650 | 2 | |2 MeSH |a Parkinson Disease: physiopathology | |
650 | 2 | |2 MeSH |a Parkinson Disease: therapy | |
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