This title appears in the Scientific Report : 2014 

Margination of micro- and nano-particles in blood flow and its effect on drug delivery
Müller, Kathrin (Corresponding Author)
Fedosov, Dmitry A. / Gompper, Gerhard
Theorie der Weichen Materie und Biophysik ; IAS-2
Theorie der Weichen Materie und Biophysik ; ICS-2
Scientific reports, 4 (2014) S. 4871
London Nature Publishing Group 2014
10.1038/srep04871
24786000
Journal Article
Soft Matter Composites
OpenAccess
Please use the identifier: http://hdl.handle.net/2128/6757 in citations.
Please use the identifier: http://dx.doi.org/10.1038/srep04871 in citations.
Drug delivery by micro- and nano-carriers enables controlled transport of pharmaceuticals to targeted sites. Even though carrier fabrication has made much progress recently, the delivery including controlled particle distribution and adhesion within the body remains a great challenge. The adhesion of carriers is strongly affected by their margination properties (migration toward walls) in the microvasculature. To investigate margination characteristics of carriers of different shapes and sizes and to elucidate the relevant physical mechanisms, we employ mesoscopic hydrodynamic simulations of blood flow. Particle margination is studied for a wide range of hematocrit values, vessel sizes, and flow rates, using two- and three-dimensional models. The simulations show that the margination properties of particles improve with increasing carrier size. Spherical particles yield slightly better margination than ellipsoidal carriers; however, ellipsoidal particles exhibit a slower rotational dynamics near a wall favoring their adhesion. In conclusion, micron-sized ellipsoidal particles are favorable for drug delivery in comparison with sub-micron spherical particles