This title appears in the Scientific Report : 2014 

Prepulse Inhibition of the Acoustic Startle Reflex in High Functioning Autism
Kohl, S.
Wolters, Carolin / Gruendler, Theo O. J. / Vogeley, Kai / Klosterk├Âtter, Joachim / Kuhn, Jens
Kognitive Neurowissenschaften; INM-3
PLoS one, 9 (2014) 3, S. e92372 -
Lawrence, Kan. PLoS 2014
24643088
10.1371/journal.pone.0092372
Journal Article
(Dys-)function and Plasticity
Pathophysiological Mechanisms of Neurological and Psychiatric Diseases
OpenAccess
Please use the identifier: http://dx.doi.org/10.1371/journal.pone.0092372 in citations.
Please use the identifier: http://hdl.handle.net/2128/7822 in citations.
High functioning autism is an autism spectrum disorder that is characterized by deficits in social interaction and communication as well as repetitive and restrictive behavior while intelligence and general cognitive functioning are preserved. According to the weak central coherence account, individuals with autism tend to process information detail-focused at the expense of global form. This processing bias might be reflected by deficits in sensorimotor gating, a mechanism that prevents overstimulation during the transformation of sensory input into motor action. Prepulse inhibition is an operational measure of sensorimotor gating, which indicates an extensive attenuation of the startle reflex that occurs when a startling pulse is preceded by a weaker stimulus, the prepulse.