This title appears in the Scientific Report :
2010
Please use the identifier:
http://hdl.handle.net/2128/4361 in citations.
Synthesis and radiofluorination of putative NMDA receptor ligands
Synthesis and radiofluorination of putative NMDA receptor ligands
In the course of this work on the synthesis of radioligands for the NMDA receptor the authentic standards and labeling precursors of four compounds with an amidine structure was performed. Synthesis of the precursors followed reaction conditions given in the literature and was successful. The imidoe...
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Personal Name(s): | Kronenberg, U. (Corresponding author) |
---|---|
Contributing Institute: |
Nuklearchemie; INM-5 |
Imprint: |
Jülich
Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag
2010
|
Physical Description: |
III, 95 p. |
Dissertation Note: |
Köln, Univ., Diss., 2010 |
Document Type: |
Book Dissertation / PhD Thesis |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Berichts des Forschungszentrums Jülich
4338 |
Subject (ZB): | |
Link: |
OpenAccess |
Publikationsportal JuSER |
In the course of this work on the synthesis of radioligands for the NMDA receptor the
authentic standards and labeling precursors of four compounds with an amidine structure was performed.
Synthesis of the precursors followed reaction conditions given in the literature and was successful. The imidoesters used for the synthesis were obtained from their
nitriles in a Pinner synthesis, while 2-hydroxybenzylamine was synthesized in a
reduction of 2-hydroxybenzonitrile using borane as a reducing agent. After a coupling
reaction of the amine and the imidoester in DMF using triethylamine as base the
precursors were obtained in good yields and purified by crystallization from methanol.
The cyclic standard compound was synthesized directly from 2-(bromomethyl)-
benzonitrile and 2-hydroxybenzylamine in a ring closing reaction. Similar to
the other precursors, crystallization from methanol produced a pure compound.... |