This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1016/j.apradiso.2007.08.001 in citations.
High molar activity of [11C]TCH346 via [11C]methyl triflate using the 'wet' [11C]CO2 reduction method
High molar activity of [11C]TCH346 via [11C]methyl triflate using the 'wet' [11C]CO2 reduction method
[(11)C]TCH346, a compound acting on the glycolytic enzyme, glycerol-aldehyde-3-phosphate dehydrogenase, was produced under optimised conditions by methylation of the desmethyl compound with no-carrier added (n.c.a.) [(11)C]methyl triflate. An i.v. injectable solution of n.c.a. [(11)C]TCH346 containi...
Saved in:
Personal Name(s): | Ermert, J. |
---|---|
Stüsgen, St. / Lang, M. / Roden, W. / Coenen, H. H. | |
Contributing Institute: |
Nuklearchemie; INB-4 |
Published in: | Applied radiation and isotopes, 66 (2008) S. 619 - 624 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2008
|
Physical Description: |
619 - 624 |
PubMed ID: |
17827025 |
DOI: |
10.1016/j.apradiso.2007.08.001 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Applied Radiation and Isotopes
66 |
Subject (ZB): | |
Publikationsportal JuSER |
[(11)C]TCH346, a compound acting on the glycolytic enzyme, glycerol-aldehyde-3-phosphate dehydrogenase, was produced under optimised conditions by methylation of the desmethyl compound with no-carrier added (n.c.a.) [(11)C]methyl triflate. An i.v. injectable solution of n.c.a. [(11)C]TCH346 containing 4040+/-1550 MBq (n=6) containing a molar activity between 40 and 5700 GBq/micromol and a radiochemical purity of >99% was obtained within 30 min (after EOB) by irradiation of nitrogen gas containing 0.5% oxygen with 16.5 MeV protons at 45 microA for 30 min. The alkylation reagent [(11)C]methyl triflate was prepared via on-line conversion of [(11)C]methyl iodide. For the formation of [(11)C]methyl iodide, [(11)C]carbon dioxide from the target chamber was reduced by a lithium aluminium hydride solution, and the methanol obtained on-line was converted using triphenylphosphine diiodide. The molar activity of [(11)C]TCH346 could be improved from 40 up to nearly 5700GB q/micromol during the optimisation of the synthesis using the same stock solution of lithium aluminium hydride solution in tetrahydrofuran. |