This title appears in the Scientific Report :
2015
Please use the identifier:
http://dx.doi.org/10.1007/s00259-014-2934-0 in citations.
Uptake and tracer kinetics of O-(2-18F-fluoroethyl)-l-tyrosine in meningiomas: preliminary results.
Uptake and tracer kinetics of O-(2-18F-fluoroethyl)-l-tyrosine in meningiomas: preliminary results.
PurposeO-(2-[18F]Fluoroethyl)-l-tyrosine (18F-FET) is a well-established PET tracer for the imaging of cerebral gliomas, but little is known about 18F-FET uptake in meningiomas. The aim of this study was to explore 18F-FET kinetics and tumour-to-background contrast in meningiomas of various histolog...
| Personal Name(s): | Cornelius, Jan F. (Corresponding Author) |
|---|---|
| Stoffels, Gabriele / Filss, Christian / Galldiks, Norbert / Slotty, Philipp / Kamp, Marcel / el Khatib, Mustafa / Hänggi, Daniel / Sabel, Michael / Felsberg, Jörg / Steiger, Hans Jakob / Coenen, Heinrich Hubert / Shah, Nadim J. / Langen, Karl-Josef | |
| Contributing Institute: |
Kognitive Neurowissenschaften; INM-3 Nuklearchemie; INM-5 Physik der Medizinischen Bildgebung; INM-4 |
| Published in: | European journal of nuclear medicine and molecular imaging, 42 (2015) 3, S. 459-467 |
| Imprint: |
Heidelberg [u.a.]
Springer-Verl.
2015
|
| DOI: |
10.1007/s00259-014-2934-0 |
| Document Type: |
Journal Article |
| Research Program: |
(Dys-)function and Plasticity |
| Publikationsportal JuSER |
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| 100 | 1 | |a Cornelius, Jan F. |0 P:(DE-HGF)0 |b 0 |e Corresponding Author | |
| 245 | |a Uptake and tracer kinetics of O-(2-18F-fluoroethyl)-l-tyrosine in meningiomas: preliminary results. | ||
| 260 | |a Heidelberg [u.a.] |c 2015 |b Springer-Verl. | ||
| 520 | |a PurposeO-(2-[18F]Fluoroethyl)-l-tyrosine (18F-FET) is a well-established PET tracer for the imaging of cerebral gliomas, but little is known about 18F-FET uptake in meningiomas. The aim of this study was to explore 18F-FET kinetics and tumour-to-background contrast in meningiomas of various histologies.MethodsA group of 24 patients with suspected cerebral meningioma on MRI/CT had an additional dynamic 18F-FET PET scan prior to surgery. Time–activity curves (TAC) of 18F-FET uptake in the tumours and tumour-to-brain ratios (TBR) for early (3 – 14 min after injection) and late 18F-FET uptake (20 – 40 min after injection) were analysed and compared with histological subtypes and WHO grade. 18F-FET uptake in critical structures in the skull base was also evaluated in terms of tumour-to-tissue (T/Tis) ratio.ResultsTBR of 18F-FET uptake in meningiomas was significantly higher in the early phase than in the late phase (3.5 ± 0.8 vs. 2.2 ± 0.3; P < 0.001). The difference in TBR between low-grade meningiomas (WHO grade I, 18 patients) and high-grade meningiomas (WHO grade II or III, 6 patients) was significant in the late phase of 18F-FET uptake (2.1 ± 0.2 vs. 2.5 ± 0.2, P = 0.003) while there was no significant difference in the early phase. ROC analysis showed that TBR of 18F-FET uptake in the late phase had significant power to differentiate low-grade from high-grade meningiomas (AUC 0.87 ± 0.18, sensitivity 83 %, specificity 83 %, optimal cut-off 2.3; P < 0.01). Evaluation of TAC yielded three different curve patterns of 18F-FET PET uptake. Combination of TBR (cut-off value 2.3) and TAC pattern slightly improved the differentiation of high-grade from low-grade meningiomas (accuracy 92 %; P = 0.001). Analysis of background radioactivity in the skull base indicated that 18F-FET uptake may be helpful in distinguishing meningioma tissue in the late phase. T/Tis ratios were >1.2 in all patients for the periorbita, sphenoidal sinus, pituitary gland, tentorium, bone and brain, in more than 90 % of patients for the mucosa and dura, but in only 63 % of patients for the cavernous sinus.Conclusion18F-FET PET may provide additional information for noninvasive grading of meningiomas and possibly for the discrimination of tumour in critical areas of the skull base. A further evaluation of 18F-FET PET in meningiomas appears to be justified. | ||
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