This title appears in the Scientific Report :
2015
Please use the identifier:
http://dx.doi.org/10.1007/s12268-015-0553-3 in citations.
Pupylierung - ein bakterielles Pendant zur Ubiquitinylierung
Pupylierung - ein bakterielles Pendant zur Ubiquitinylierung
Pupylation is a reversible process in which the prokaryotic ubiquitin-like protein Pup is attached to target proteins by an isopeptide bond. It occurs mainly in Actinobacteria and was discovered in Mycobacterium tuberculosis, where pupylated proteins are targeted for proteasomal degradation, thus re...
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Personal Name(s): | Küberl, Andreas |
---|---|
Polen, Tino / Bott, Michael (Corresponding Author) | |
Contributing Institute: |
Biotechnologie; IBG-1 |
Published in: | Biospektrum, 21 (2015) 2, S. 158 - 160 |
Imprint: |
Heidelberg
Spektrum
2015
|
DOI: |
10.1007/s12268-015-0553-3 |
Document Type: |
Journal Article |
Research Program: |
Biotechnology |
Publikationsportal JuSER |
Pupylation is a reversible process in which the prokaryotic ubiquitin-like protein Pup is attached to target proteins by an isopeptide bond. It occurs mainly in Actinobacteria and was discovered in Mycobacterium tuberculosis, where pupylated proteins are targeted for proteasomal degradation, thus resembling ubiquitination in eukaryotes. Interestingly, species without a proteasome like Corynebacterium glutamicum also perform pupylation. Key features of this protein modification are summarized here. |