Description: Modeling the Spatial Reach of the LFP

This title appears in the Scientific Report : 2011

Modeling the Spatial Reach of the LFP

The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of...

Personal Name(s):	Linden, H.
	Tetzlaff, T. / Potjans, T.C. / Pettersen, K.H. / Grün, S. / Diesmann, M. / Einevoll, G.T.
Contributing Institute:	Computational and Systems Neuroscience; INM-6
Published in:	Neuron, 72 (2011) S. 859 - 872
Imprint:	[Cambridge, Mass.] Cell Press 2011
Physical Description:	859 - 872
PubMed ID:	22153380
DOI:	10.1016/j.neuron.2011.11.006
Document Type:	Journal Article
Research Program:	Brain-inspired multiscale computation in neuromorphic hybrid systems Pathophysiological Mechanisms of Neurological and Psychiatric Diseases Neurowissenschaften
Series Title:	Neuron 72
Subject (ZB):	Animals Cerebral Cortex: cytology Cerebral Cortex: physiology Computer Simulation Electrodes Electroencephalography Evoked Potentials: physiology Humans Models, Neurological Nerve Net: physiology Neurons: classification Neurons: physiology Synapses: physiology Synaptic Potentials: physiology J
	Publikationsportal JuSER

Please use the identifier: http://dx.doi.org/10.1016/j.neuron.2011.11.006 in citations.

The local field potential (LFP) reflects activity of many neurons in the vicinity of the recording electrode and is therefore useful for studying local network dynamics. Much of the nature of the LFP is, however, still unknown. There are, for instance, contradicting reports on the spatial extent of the region generating the LFP. Here, we use a detailed biophysical modeling approach to investigate the size of the contributing region by simulating the LFP from a large number of neurons around the electrode. We find that the size of the generating region depends on the neuron morphology, the synapse distribution, and the correlation in synaptic activity. For uncorrelated activity, the LFP represents cells in a small region (within a radius of a few hundred micrometers). If the LFP contributions from different cells are correlated, the size of the generating region is determined by the spatial extent of the correlated activity.