This title appears in the Scientific Report :
2015
Please use the identifier:
http://dx.doi.org/10.1007/s00417-014-2652-0 in citations.
The effects of iodoacetic acid on the mouse retina
The effects of iodoacetic acid on the mouse retina
Background:To characterize the effects of intravitreal injections of iodoacetic acid (IAA) in comparison to its systemic application as a measure to induce unilateral photoreceptor degeneration.Methods:Seven-week-old C57BL/6 J mice received either intravitreal injections of IAA or systemic treatment...
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Personal Name(s): | Rösch, Sarah |
---|---|
Johnen, Sandra / Mazinani, Babac / Müller, Frank / Pfarrer, Christiane / Walter, Peter (Corresponding author) | |
Contributing Institute: |
Zelluläre Biophysik; ICS-4 |
Published in: | Graefe's archive for clinical and experimental ophthalmology, 253 (2015) 1, S. 25 - 35 |
Imprint: |
Berlin
Springer
2015
|
DOI: |
10.1007/s00417-014-2652-0 |
PubMed ID: |
24827634 |
Document Type: |
Journal Article |
Research Program: |
Physical Basis of Diseases |
Publikationsportal JuSER |
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520 | |a Background:To characterize the effects of intravitreal injections of iodoacetic acid (IAA) in comparison to its systemic application as a measure to induce unilateral photoreceptor degeneration.Methods:Seven-week-old C57BL/6 J mice received either intravitreal injections of IAA or systemic treatment (intraperitoneal vs intravenous) and were observed in the following 5 weeks using ERG, OCT, and histology.Results:Systemic treatment with IAA induced high toxic effects and a high mortality in contrast to the intravitreal injection. Intraperitoneal application had no effect on the retina. Intravenous application of 2 × 30 mg/kg BW IAA (time between injections 3.5 h) resulted in an extinction of the ERG and a thinning of the retina, in particular of the outer nuclear layer (ONL) indicating photoreceptor degeneration. Animals receiving intravitreal injections developed cataracts already at low concentrations (up to 100 % at 0.25 mg/kg BW). Higher intravitreal IAA doses led to extinguished ERGs. In histology, a thinning of the entire retina was observed that was most prominent in the inner part of the retina.Conclusions:In contrast to intraperitoneal administration, intravenous application of IAA led to a selective photoreceptor degeneration. After intravitreal injection, dense cataracts were already observed at concentrations lower than those needed to induce changes in the ERG. ERG results must be interpreted carefully. A thinning of all retinal layers rather than a specific outer retinal degeneration was observed upon intravitreal injection. IAA is not a useful model to induce outer retinal degeneration in mice. | ||
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