This title appears in the Scientific Report :
2012
Please use the identifier:
http://dx.doi.org/10.1002/elps.201100683 in citations.
Forensic analysis of mesembrine alkaloids in Sceletium tortuosum by nonaqueous capillary electrophoresis mass spectrometry
Forensic analysis of mesembrine alkaloids in Sceletium tortuosum by nonaqueous capillary electrophoresis mass spectrometry
The consumption of legal and illegal drugs follows an organic trend comparable to the current trend in food consumption. The investigation of such drugs is therefore of interest to characterize the active ingredients of plants and drug preparations. A new method of nonaqueous capillary electrophores...
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Personal Name(s): | Roscher, J. |
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Posch, T.N. / Pütz, M. / Huhn, C. | |
Contributing Institute: |
Zentralabteilung für Chemische Analysen; ZCH |
Published in: | Electrophoresis, 33 (2012) S. 1567 - 1570 |
Imprint: |
Weinheim
Wiley-Blackwell
2012
|
Physical Description: |
1567 - 1570 |
PubMed ID: |
22736358 |
DOI: |
10.1002/elps.201100683 |
Document Type: |
Journal Article |
Research Program: |
Techniken, Innovation und Gesellschaft (TIG) |
Series Title: |
Electrophoresis
33 |
Subject (ZB): | |
Publikationsportal JuSER |
The consumption of legal and illegal drugs follows an organic trend comparable to the current trend in food consumption. The investigation of such drugs is therefore of interest to characterize the active ingredients of plants and drug preparations. A new method of nonaqueous capillary electrophoresis coupled to mass spectrometry (NACE-MS) as a powerful tool for the separation of complex alkaloid mixtures in difficult matrices is presented in this study for the analysis of samples of Sceletium tortuosum and drug products called Kanna made thereof. The method was found to be suitable for the investigation of the alkaloid composition and relative quantification of the ingredients. It proved of value to separate a large number of isobaric compounds, most probably including diastereomers, double-bond isomers, and further structurally closely related compounds. A comparison of plant samples from different vendors, self-fermented samples, and products ready for consumption was made. The high separation power obtained allowed a better description of the chemotypic differences of plant samples as well as Kanna preparations compared to other methods presented in the literature so far. Thus, the use of the NACE-MS enables a new perspective on the alkaloid profile of Sceletium species. |