This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1209/0295-5075/83/20003 in citations.
The generaton of Parkinsonian tremor as revealed by dircetional coupling analysis
The generaton of Parkinsonian tremor as revealed by dircetional coupling analysis
To reveal the dynamic mechanism underlying Parkinsonian resting tremor, we applied a phase dynamics modelling technique to local field potentials and accelerometer signals recorded in three Parkinsonian patients with implanted depth electrodes. We detect a bidirectional coupling between the subcorti...
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Personal Name(s): | Smirnov, D. A. |
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Barnikol, U. B. / Barnikol, T.T. / Bezruchko, B.P. / Hauptmann, C. / Bührle, C. / Maarouf, M. / Sturm, V. / Freund, H.-J. / Tass, P. A. | |
Contributing Institute: |
Institut für Neurowissenschaften und Biophysik - Medizin; INB-3 |
Published in: | epl, 83 (2008) |
Imprint: |
Les Ulis
EDP Sciences
2008
|
DOI: |
10.1209/0295-5075/83/20003 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Europhysics Letters
83 |
Subject (ZB): | |
Publikationsportal JuSER |
To reveal the dynamic mechanism underlying Parkinsonian resting tremor, we applied a phase dynamics modelling technique to local field potentials and accelerometer signals recorded in three Parkinsonian patients with implanted depth electrodes. We detect a bidirectional coupling between the subcortical oscillation and the tremor. The tremor -> brain driving is a linear effect with a small delay corresponding to the neural transmission time. In contrast, the brain -> tremor driving is a nonlinear effect with a long delay in the order of 1-2 mean tremor periods. Our results are well reproduced for an ensemble of 41 tremor epochs in three Parkinsonian patients and confirmed by surrogate data tests and model simulations. The uncovered mechanism of tremor generation suggests to specifically counteract tremor by desynchronizing the subcortical oscillatory neural activity. Copyright (C) EPLA, 2008. |