Description: Salt-Induced Universal Slowing Down of the Short-Time Self-Diffusion of a Globular Protein in Aqueous Solution

This title appears in the Scientific Report : 2015

Salt-Induced Universal Slowing Down of the Short-Time Self-Diffusion of a Globular Protein in Aqueous Solution

The short-time self-diffusion D of the globular model protein bovine serum albumin in aqueous (D2O) solutions has been measured comprehensively as a function of the protein and trivalent salt (YCl3) concentration, noted cp and cs, respectively. We observe that D follows a universal master curve D(cs...

Personal Name(s):	Grimaldo, Marco
	Roosen-Runge, Felix / Hennig, Marcus / Zanini, Fabio / Zhang, Fajun / Zamponi, Michaela / Jalarvo, Niina / Schreiber, Frank / Seydel, Tilo (Corresponding author)
Contributing Institute:	Neutronenstreuung; ICS-1 JCNS-SNS; JCNS-SNS JCNS-FRM-II; JCNS-FRM-II Neutronenstreuung; JCNS-1
Published in:	The @journal of physical chemistry letters, 6 (2015) 13, S. 2577 - 2582
Imprint:	Washington, DC ACS 2015
DOI:	10.1021/acs.jpclett.5b01073
PubMed ID:	26266736
Document Type:	Journal Article
Research Program:	Soft Matter, Health and Life Sciences Jülich Centre for Neutron Research (JCNS) Functional Macromolecules and Complexes
Subject (ZB):	Soft Condensed Matter > 0 Biology > 1 Chemistry > 2 Health and Life > 1 Health and Life > 0
Link:	OpenAccess OpenAccess
	Publikationsportal JuSER

Please use the identifier: http://hdl.handle.net/2128/9283 in citations.
Please use the identifier: http://hdl.handle.net/2128/9282 in citations.
Please use the identifier: http://dx.doi.org/10.1021/acs.jpclett.5b01073 in citations.

The short-time self-diffusion D of the globular model protein bovine serum albumin in aqueous (D2O) solutions has been measured comprehensively as a function of the protein and trivalent salt (YCl3) concentration, noted cp and cs, respectively. We observe that D follows a universal master curve D(cs,cp) = D(cs = 0,cp) g(cs/cp), where D(cs = 0,cp) is the diffusion coefficient in the absence of salt and g(cs/cp) is a scalar function solely depending on the ratio of the salt and protein concentration. This observation is consistent with a universal scaling of the bonding probability in a picture of cluster formation of patchy particles. The finding corroborates the predictive power of the description of proteins as colloids with distinct attractive ion-activated surface patches.