This title appears in the Scientific Report :
2015
Please use the identifier:
http://hdl.handle.net/2128/9283 in citations.
Please use the identifier: http://hdl.handle.net/2128/9282 in citations.
Please use the identifier: http://dx.doi.org/10.1021/acs.jpclett.5b01073 in citations.
Salt-Induced Universal Slowing Down of the Short-Time Self-Diffusion of a Globular Protein in Aqueous Solution
Salt-Induced Universal Slowing Down of the Short-Time Self-Diffusion of a Globular Protein in Aqueous Solution
The short-time self-diffusion D of the globular model protein bovine serum albumin in aqueous (D2O) solutions has been measured comprehensively as a function of the protein and trivalent salt (YCl3) concentration, noted cp and cs, respectively. We observe that D follows a universal master curve D(cs...
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Personal Name(s): | Grimaldo, Marco |
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Roosen-Runge, Felix / Hennig, Marcus / Zanini, Fabio / Zhang, Fajun / Zamponi, Michaela / Jalarvo, Niina / Schreiber, Frank / Seydel, Tilo (Corresponding author) | |
Contributing Institute: |
Neutronenstreuung; ICS-1 JCNS-SNS; JCNS-SNS JCNS-FRM-II; JCNS-FRM-II Neutronenstreuung; JCNS-1 |
Published in: | The @journal of physical chemistry letters, 6 (2015) 13, S. 2577 - 2582 |
Imprint: |
Washington, DC
ACS
2015
|
DOI: |
10.1021/acs.jpclett.5b01073 |
PubMed ID: |
26266736 |
Document Type: |
Journal Article |
Research Program: |
Soft Matter, Health and Life Sciences Jülich Centre for Neutron Research (JCNS) Functional Macromolecules and Complexes |
Subject (ZB): | |
Link: |
OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/9282 in citations.
Please use the identifier: http://dx.doi.org/10.1021/acs.jpclett.5b01073 in citations.
The short-time self-diffusion D of the globular model protein bovine serum albumin in aqueous (D2O) solutions has been measured comprehensively as a function of the protein and trivalent salt (YCl3) concentration, noted cp and cs, respectively. We observe that D follows a universal master curve D(cs,cp) = D(cs = 0,cp) g(cs/cp), where D(cs = 0,cp) is the diffusion coefficient in the absence of salt and g(cs/cp) is a scalar function solely depending on the ratio of the salt and protein concentration. This observation is consistent with a universal scaling of the bonding probability in a picture of cluster formation of patchy particles. The finding corroborates the predictive power of the description of proteins as colloids with distinct attractive ion-activated surface patches. |