This title appears in the Scientific Report :
2003
Please use the identifier:
http://dx.doi.org/10.1016/S0969-8051(03)00023-4 in citations.
Comparison of Fluorotyrosines and Methionine Uptake in F98 Rat Gliomas
Comparison of Fluorotyrosines and Methionine Uptake in F98 Rat Gliomas
The transport mechanisms of O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) and 2-[F-18]fluoro-L-tyrosine (FTyr) were compared to those of [H-3]-Methyl-L-methionine (MET) in F98 rat glioma cells in vitro and by tumor imaging by ex vivo dual tracer autoradiography in F98 rat gliomas. Both, FET and FTyr exhi...
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Personal Name(s): | Langen, K.-J. |
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Jarosch, M. / Mühlensiepen, H. / Hamacher, K. / Bröer, S. / Jansen, P. / Zilles, K. / Coenen, H. H. | |
Contributing Institute: |
Zentralinstitut für Angewandte Mathematik; ZAM Institut für Medizin; IME Institut für Nuklearchemie; INC |
Published in: | Nuclear medicine and biology, 30 (2003) S. 501 - 508 |
Imprint: |
Amsterdam [u.a.]
Elsevier
2003
|
Physical Description: |
501 - 508 |
DOI: |
10.1016/S0969-8051(03)00023-4 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften Betrieb und Weiterentwicklung des Höchstleistungsrechners |
Series Title: |
Nuclear Medicine and Biology
30 |
Subject (ZB): | |
Publikationsportal JuSER |
The transport mechanisms of O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) and 2-[F-18]fluoro-L-tyrosine (FTyr) were compared to those of [H-3]-Methyl-L-methionine (MET) in F98 rat glioma cells in vitro and by tumor imaging by ex vivo dual tracer autoradiography in F98 rat gliomas. Both, FET and FTyr exhibited similar transport characteristics in F98 glioma cells compared to MET, i.e. mainly a sodium dependent transport similar to system B-0,B-+ and sodium independent transport via system L. Radioactivity of FET in the acid precipitable fraction was <1% after 120 min incubation time while FTyr and MET exhibited a 15-18% incorporation into proteins. Comparison of FET and FTyr with MET uptake in F98 rat gliomas demonstrated a significant correlation of tumor to brain ratios and a similar intratumoral tracer distribution pattern. (C) 2003 Elsevier Inc. All rights reserved. |