This title appears in the Scientific Report :
2015
Please use the identifier:
http://dx.doi.org/10.1038/srep13222 in citations.
Please use the identifier: http://hdl.handle.net/2128/9555 in citations.
QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
QIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
Strong evidence exists for a central role of amyloid β-protein (Aβ) oligomers in the pathogenesis of Alzheimer’s disease. We have developed a fast, reliable and robust in vitro assay, termed QIAD, to quantify the effect of any compound on the Aβ aggregate size distribution. Applying QIAD, we studied...
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Personal Name(s): | Brener, Oleksandr |
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Dunkelmann, Tina / Gremer, Lothar / van Groen, Thomas / Mirecka, Ewa A. / Kadish, Inga / Willuweit, Antje / Kutzsche, Janine / Jürgens, Dagmar / Rudolph, Stephan / Tusche, Markus / Bongen, Patrick / Pietruszka, Jörg / Oesterhelt, Filipp / Langen, Karl-Josef / Demuth, Hans-Ulrich / Janssen, Arnold / Hoyer, Wolfgang / Funke, Susanne A. / Nagel-Steger, Luitgard / Willbold, Dieter (Corresponding author) | |
Contributing Institute: |
Biotechnologie; IBG-1 Institut für Bioorganische Chemie (HHUD); IBOC Strukturbiochemie; ICS-6 |
Published in: | Scientific reports, 5 (2015) S. 13222 |
Imprint: |
London
Nature Publishing Group
2015
|
DOI: |
10.1038/srep13222 |
PubMed ID: |
26394756 |
Document Type: |
Journal Article |
Research Program: |
Biotechnology Physical Basis of Diseases |
Link: |
Get full text OpenAccess OpenAccess |
Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/9555 in citations.
Strong evidence exists for a central role of amyloid β-protein (Aβ) oligomers in the pathogenesis of Alzheimer’s disease. We have developed a fast, reliable and robust in vitro assay, termed QIAD, to quantify the effect of any compound on the Aβ aggregate size distribution. Applying QIAD, we studied the effect of homotaurine, scyllo-inositol, EGCG, the benzofuran derivative KMS88009, ZAβ3W, the D-enantiomeric peptide D3 and its tandem version D3D3 on Aβ aggregation. The predictive power of the assay for in vivo efficacy is demonstrated by comparing the oligomer elimination efficiency of D3 and D3D3 with their treatment effects in animal models of Alzheimer´s disease. |