This title appears in the Scientific Report : 2000 

A cGMP-signaling pathway in a subset of olfactory sensory neurons
Meyer, M. R.
Angele, A. / Kremmer, E. / Kaupp, U. B. / Müller, F.
Institut für Biologische Informationsverarbeitung; IBI
Proceedings of the National Academy of Sciences of the United States of America, 97 (2000) S. 10595 - 10600
Washington, DC Academy 2000
10595 - 10600
Journal Article
Zelluläre Signalverarbeitung
Proceedings of the National Academy of Sciences of the United States of America 97
J
OpenAccess
Please use the identifier: http://hdl.handle.net/2128/2818 in citations.
It is well established that signal transduction in sensory neurons of the rat olfactory epithelium involves a cAMP-signaling pathway. However, a small number of olfactory neurons specifically express cGMP-signaling components, namely a guanylyl cyclase (CC-D) and a cGMP-stimulated phosphodiesterase (PDE2). Here, we show that this subset of olfactory neurons expressing GC-D and PDE2 does also express the subunit of a cGMP-selective cyclic nucleotidegated (CNG) channel that has been previously identified in cone photoreceptors. Further, components of the prototypical cAMP-signaling pathway could not be detected in this subpopulation of cells. These results imply that these neurons use an alternative signaling pathway, with cGMP as the intracellular messenger, and that, in these cells, the receptor current is initiated by the opening of cGMP-gated channels.