This title appears in the Scientific Report :
2003
Please use the identifier:
http://dx.doi.org/10.1016/S0920-9964(02)00325-0 in citations.
Automated image analysis of disturbed cytoarchitecture in Brodmann area 10 in schizophrenia
Automated image analysis of disturbed cytoarchitecture in Brodmann area 10 in schizophrenia
To detect cytoarchitectonic abnormalities in the Brodmann area 10 (BA10) of schizophrenic patients, we applied a newly modified variant of the gray-level index (GLI) method as fully automated image analysis method providing cytoarchitectonic profiles of the whole cortex as a scanning tool. Microscop...
Saved in:
Personal Name(s): | Vogeley, K. |
---|---|
Tepest, R. / Schneider-Axmann, T. / Hütte, H. / Zilles, K. / Honer, W. G. / Falkai, P. | |
Contributing Institute: |
Institut für Medizin; IME |
Published in: | Schizophrenia research, 62 (2003) S. 133 - 140 |
Imprint: |
Amsterdam [u.a.]
Elsevier Science
2003
|
Physical Description: |
133 - 140 |
PubMed ID: |
12765753 |
DOI: |
10.1016/S0920-9964(02)00325-0 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Schizophrenia Research
62 |
Subject (ZB): | |
Publikationsportal JuSER |
To detect cytoarchitectonic abnormalities in the Brodmann area 10 (BA10) of schizophrenic patients, we applied a newly modified variant of the gray-level index (GLI) method as fully automated image analysis method providing cytoarchitectonic profiles of the whole cortex as a scanning tool. Microscopic images of silver-stained sections of 20 schizophrenic brains compared to 20 control brains were automatically scanned and binarized at an adaptive threshold. In 30 measuring fields through the whole cortical depth, the dependent measure of gray-level index (GLI) as the area-percentage covered by perikarya in a measuring field was obtained providing a cytoarchitectonic profile. GLI is an estimate of the volume density of perikarya. A statistical analysis of mean GLI values was performed for six compartments, separately, approximately corresponding to cortical layers. Results revealed significant GLI reductions in schizophrenic brains in all six compartments suggesting either a decreased perikarya fraction or an increased neuropil fraction. The described automated image analysis method providing cytoarchitectonic profiles can be applied as a fast and observer-independent scanning tool to detect cytoarchitectonic abnormalities in multiple brain regions. (C) 2002 Elsevier Science B.V. All rights reserved. |