This title appears in the Scientific Report : 2003 

Radiosynthesis and in vitro stability evaluation of various radioiodine-labelled ß-iodoalkylether prosthetic groups linked to model compounds
Rossouw, D. D.
Coenen, H. H.
Institut für Nuklearchemie; INC
Nuclear medicine and biology, 30 (2003) S. 373 - 380
Amsterdam [u.a.] Elsevier 2003
373 - 380
10.1016/S0969-8051(02)00453-5
Journal Article
Neurowissenschaften
Nuclear Medicine and Biology 30
J
Please use the identifier: http://dx.doi.org/10.1016/S0969-8051(02)00453-5 in citations.
A systematic comparative investigation into the in vitro radiochemical stabilities of model compounds containing radioiodinated beta-iodoethoxyl units and derivatives thereof, as well as those of similar compounds lacking a beta-oxygen to serve as control references, was undertaken. The radioiodinations were carried out in fair to modest yields by means of substitution of a tosyl group by iodide. Stability evaluations were carried out by incubating the labeled compounds in human blood serum at 37degreesC and measuring free radioiodide by means of radio-HPLC and radio-TLC. The compounds containing beta-iodoethoxyl units displayed much superior stabilities than those without, while the presence of small alkyl or aryl groups in such a unit rendered an additional degree of stability to the carbon-iodine bond, especially over a long period. (C) 2003 Elsevier Inc. All rights reserved.