This title appears in the Scientific Report :
2003
Please use the identifier:
http://dx.doi.org/10.1016/S0969-8051(02)00453-5 in citations.
Radiosynthesis and in vitro stability evaluation of various radioiodine-labelled ß-iodoalkylether prosthetic groups linked to model compounds
Radiosynthesis and in vitro stability evaluation of various radioiodine-labelled ß-iodoalkylether prosthetic groups linked to model compounds
A systematic comparative investigation into the in vitro radiochemical stabilities of model compounds containing radioiodinated beta-iodoethoxyl units and derivatives thereof, as well as those of similar compounds lacking a beta-oxygen to serve as control references, was undertaken. The radioiodinat...
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Personal Name(s): | Rossouw, D. D. |
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Coenen, H. H. | |
Contributing Institute: |
Institut für Nuklearchemie; INC |
Published in: | Nuclear medicine and biology, 30 (2003) S. 373 - 380 |
Imprint: |
Amsterdam [u.a.]
Elsevier
2003
|
Physical Description: |
373 - 380 |
DOI: |
10.1016/S0969-8051(02)00453-5 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Nuclear Medicine and Biology
30 |
Subject (ZB): | |
Publikationsportal JuSER |
A systematic comparative investigation into the in vitro radiochemical stabilities of model compounds containing radioiodinated beta-iodoethoxyl units and derivatives thereof, as well as those of similar compounds lacking a beta-oxygen to serve as control references, was undertaken. The radioiodinations were carried out in fair to modest yields by means of substitution of a tosyl group by iodide. Stability evaluations were carried out by incubating the labeled compounds in human blood serum at 37degreesC and measuring free radioiodide by means of radio-HPLC and radio-TLC. The compounds containing beta-iodoethoxyl units displayed much superior stabilities than those without, while the presence of small alkyl or aryl groups in such a unit rendered an additional degree of stability to the carbon-iodine bond, especially over a long period. (C) 2003 Elsevier Inc. All rights reserved. |