This title appears in the Scientific Report : 2003 

Obsessive-compulsive disorder: Development of demand-controlled deep brain stimulation with methods from stochastic phase resetting
Tass, P. A.
Klosterkötter, J. / Schneider, F. / Lenartz, D. / Koulousakis, A. / Sturm, V.
Institut für Medizin; IME
Neuropsychopharmacology, 28 (2003) S. s27 - s34
London Nature Publ. Group 2003
s27 - s34
12827141
10.1038/sj.npp.1300144
Journal Article
Neurowissenschaften
Neuropsychopharmacology 28
J
Please use the identifier: http://dx.doi.org/10.1038/sj.npp.1300144 in citations.
Synchronization of neuronal firing is a hallmark of several neurological diseases. Recently, stimulation techniques have been developed which make it possible to desynchronize oscillatory neuronal activity in a mild and effective way, without suppressing the neurons' firing. As yet, these techniques are being used to establish demand-controlled deep brain stimulation (DBS) techniques for the therapy of movement disorders like severe Parkinson's disease or essential tremor. We here present a first conceptualization suggesting that the nucleus accumbens is a promising target for the standard, that is, permanent high-frequency, DBS in patients with severe and chronic obsessive-compulsive disorder (OCD). In addition, we explain how demand-controlled DBS techniques may be applied to the therapy of OCD in those cases that are refractory to behavioral therapies and pharmacological treatment.