This title appears in the Scientific Report : 2003 

FDG PET imaging in hereditary thyroid cancer
Boer, A.
Szakall, S. / Klein, I. / Kasler, M. / Vincze, B. / Tron, L. / Gödeny, M. / Herzog, H. / Peter, I. / Esik, O.
Institut für Medizin; IME
European journal of surgical oncology, 29 (2003) S. 922 - 928
Burlington, Mass. Harcourt 2003
922 - 928
Journal Article
European Journal of Surgical Oncology 29
Please use the identifier: in citations.
Aim: To report the role of different imaging methods in staging individuals with multiple endocrine neoplasia 2A (MEN2A) or familial medullary thyroid carcinoma (FMTC). Material and methods: Fourteen newly diagnosed gene carriers underwent cervical ultrasound scanning (US), cervical and mediastinal CT, MRI and whole-body meta-[(131) I]iodobenzylguanidine (MIBG) scintigraphy and [F-18]fluorodeoxyglucose (FDG) PET scanning.Results: US identified seven true primary cancer. CT and MRI located only tumors greater than or equal to5 mm in diameter. MIBG scintigraphy and FDG PET could not identify MTC foci within the thyroid. Whole-body FDG PET identified two true-positive and one false-positive lymph node metastases. MIBG scintigraphy did not identify lymph node metastases. Total thyroidectomy was performed in 12 cases, and subtotal thyroidectomy in two subjects.Conclusions: Whole-body FDG PET and cervical US help stage individuals carrying mutant genes verifying MEN2A or FMTC. (C) 2003 Elsevier Ltd. All rights reserved.