This title appears in the Scientific Report :
2001
Enantioselective synthesis of both enantiomers of various propargylic alcohols by use of two oxidoreductases
Enantioselective synthesis of both enantiomers of various propargylic alcohols by use of two oxidoreductases
The oxidoreductases Lactobacillus brevis alcohol dehydrogenase (LBADH) and Candida parapsilosis carbonyl reductase (CPCR) are suitable catalysts for the reduction of ketones to afford enantiopure sec. alcohols. A broad variety of alkynones (1, 3, and 5) are accepted as substrates and the correspondi...
Saved in:
Personal Name(s): | Schubert, T. |
---|---|
Hummel, W. / Kula, M.-R. / Müller, M. | |
Contributing Institute: |
Biotechnologie 2; IBT-2 |
Published in: | European journal of organic chemistry, 22 (2001) S. 4181 - 4187 |
Imprint: |
Weinheim
Wiley-VCH Verl.
2001
|
Physical Description: |
4181 - 4187 |
Document Type: |
Journal Article |
Research Program: |
Verfahrenstechnik zur mikrobiellen Gewinnung von Primärmetaboliten |
Series Title: |
European Journal of Organic Chemistry
22 |
Subject (ZB): | |
Publikationsportal JuSER |
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245 | |a Enantioselective synthesis of both enantiomers of various propargylic alcohols by use of two oxidoreductases | ||
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520 | |a The oxidoreductases Lactobacillus brevis alcohol dehydrogenase (LBADH) and Candida parapsilosis carbonyl reductase (CPCR) are suitable catalysts for the reduction of ketones to afford enantiopure sec. alcohols. A broad variety of alkynones (1, 3, and 5) are accepted as substrates and the corresponding propargylic alcohols (2, 4, and 6) are obtained in good yield and excellent enantiomeric excess. By changing the steric demand of the substituents the ee values can be adjusted and even the configurations of the products can be altered. | ||
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653 | 2 | 0 | |2 Author |a oxidoreductases |
653 | 2 | 0 | |2 Author |a reductions |
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