This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1016/j.jmb.2008.06.086 in citations.
Ligand binding mode of GABA(A) receptor-associated protein
Ligand binding mode of GABA(A) receptor-associated protein
The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein comp...
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Personal Name(s): | Weiergräber, O. H. |
---|---|
Stangler, T. / Thielmann, Y. / Mohrlüder, J. / Wiesehan, K. / Willbold, D. | |
Contributing Institute: |
Molekulare Biophysik; INB-2 |
Published in: | Journal of molecular biology, 381 (2008) S. 1320 - 1331 |
Imprint: |
Amsterdam [u.a.]
Elsevier
2008
|
Physical Description: |
1320 - 1331 |
PubMed ID: |
18638487 |
DOI: |
10.1016/j.jmb.2008.06.086 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Journal of Molecular Biology
381 |
Subject (ZB): | |
Publikationsportal JuSER |
The gamma-aminobutyric acid type A (GABA(A)) receptor-associated protein is a versatile adaptor protein playing an important role in intracellular vesicle trafficking, particularly in neuronal cells. We present the X-ray structure of the soluble form of human GABA(A) receptor-associated protein complexed with a high-affinity synthetic peptide at 1.3 A resolution. The data shed light on the probable binding modes of key interaction partners, including the GABA(A) receptor and the cysteine protease Atg4. The resulting models provide a structural background for further investigation of the unique biological properties of this protein. |