Description: Cerebral glucose transport implies individualized glial cell function

This title appears in the Scientific Report : 2001

Cerebral glucose transport implies individualized glial cell function

Previous positron emission tomography (PET) measurements of cerebral glucose transport using [11C]-3-O-methylglucose (CMG) suggested an interindividual variation in the values of the rate constant of tracer outflow (k(2)) larger than that for the clearance rate of inflow (K-1). These two parameters...

Personal Name(s):	Feinendegen, L. E.
	Herzog, H. / Thompson, K. H.
Contributing Institute:	Institut für Medizin; IME
Published in:	Journal of cerebral blood flow & metabolism, 21 (2001) S. 1160 - 1170
Imprint:	[s.l.] Ovid 2001
Physical Description:	1160 - 1170
Document Type:	Journal Article
Research Program:	Signaltransduktion
Series Title:	Journal of Cerebral Blood Flow and Metabolism 21
Subject (ZB):	J brain glucose transport individualized glial function
	Publikationsportal JuSER

Previous positron emission tomography (PET) measurements of cerebral glucose transport using [11C]-3-O-methylglucose (CMG) suggested an interindividual variation in the values of the rate constant of tracer outflow (k(2)) larger than that for the clearance rate of inflow (K-1). These two parameters were examined in healthy cerebral cortex by dynamic PET in 4 men and 2 women (aged 24 to 73 years) without neurologic disease, and in 1 man (42 years) with a recent left hemispheric cerebral infarction under normoglycemia (average blood plasma d-glucose concentration, 5.44 +/- 1.94 mu mol/mL) and again under hyperglycemia (average, 10.24 +/- 1.44 mu mol/mL). Time-radioactivity curves were obtained from healthy cortex (grey matter) and plasma and analyzed for the Values or K-1 and k(2) by two graphical approaches and two fitting procedures. Both K-1 and k(2) significantly declined with increasing plasma glucose levels. A highly significant interindividual but not intraindividual variability for k(2) was found at normoglycernia and hyperglycemia. The interindividual variability of K-1, although borderline significant, was less than that of k(2). Accordingly variable were the distribution volumes K-1/k(2). These data suggest individualized glial cell function and may be relevant to pathogenesis of neuropsychiatric disease.