This title appears in the Scientific Report :
2005
Please use the identifier:
http://dx.doi.org/10.1016/j.abb.2005.04.021 in citations.
1a,25-Dihydroxy-vitamin D3 in combination with 17b-estradiol lowers the cortical expression of heat shock protein-27 following experimentally induced focal cortical ischemia in rats
1a,25-Dihydroxy-vitamin D3 in combination with 17b-estradiol lowers the cortical expression of heat shock protein-27 following experimentally induced focal cortical ischemia in rats
1alpha,25-(OH)(2)-vitamin-D(3) (1,25-D(3)) and 17beta-estradiol are both known to act neuroprotective in certain experimental in vitro and in vivo settings. We studied the effects of 1,25-D(3) or 17beta-estradiol or their combined application on heat shock protein-27 (HSP-27) distribution after foca...
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Personal Name(s): | Losem-Heinrichs, E. |
---|---|
Görg, B. / Redecker, C. / Schleicher, A. / Witte, O. W. / Zilles, K. / Bidmon, H. J. | |
Contributing Institute: |
Institut für Medizin; IME |
Published in: | Archives of biochemistry and biophysics, 439 (2005) S. 70 - 79 |
Imprint: |
San Diego, Calif.
Elsevier
2005
|
Physical Description: |
70 - 79 |
DOI: |
10.1016/j.abb.2005.04.021 |
PubMed ID: |
15922286 |
Document Type: |
Journal Article |
Research Program: |
Neurowissenschaften |
Series Title: |
Archives of Biochemistry and Biophysics
439 |
Subject (ZB): | |
Publikationsportal JuSER |
1alpha,25-(OH)(2)-vitamin-D(3) (1,25-D(3)) and 17beta-estradiol are both known to act neuroprotective in certain experimental in vitro and in vivo settings. We studied the effects of 1,25-D(3) or 17beta-estradiol or their combined application on heat shock protein-27 (HSP-27) distribution after focal cortical ischemia using the photothrombosis model. HSP-27 is a well-established marker of the cerebral oxidative stress response and a potent inhibitor of apoptosis. Lesioned rats were injected i.p. one hour after injury with either 1 microg 1,25-D(3)/kg or 7 microg 17beta-estradiol/kg or a combination of both steroids. Groups of non-lesioned steroid-treated rats and lesioned, solvent-treated rats served as controls. Treatment with both steroids did not affect the size of the lesion. In addition, 17beta-estradiol resulted in significant reduction of HSP-27 induction, whereas the combination of 1,25-D(3)+17beta-estradiol resulted in a highly significant reduction of HSP-27 within the infracted cerebral cortex, indicating that both steroids act synergistically in a protective manner. |