Description: [18F]fluorophenyl organometallics as intermediates of no-carrier-added 18F-fluoroarylation reactions

This title appears in the Scientific Report : 2007

[18F]fluorophenyl organometallics as intermediates of no-carrier-added 18F-fluoroarylation reactions

Based on the recent availability of no-carrier-added (n.c.a.) 1-bromo-4-[F-18]fluorobenzene with high radiochemical yield, the 4[F-18]fluorophenyl compounds of lithium, sodium and magnesium can now also effectively be prepared. Thus, [F-18]fluoroarene reagents with a nucleophilic reaction centre are...

Personal Name(s):	Ermert, J.
	Ludwig, T. / Gail, R. / Coenen, H. H.
Contributing Institute:	Nuklearchemie; INB-4
Published in:	Journal of organometallic chemistry, 692 (2007) S. 4084 - 4092
Imprint:	New York, NY [u.a.] Elsevier 2007
Physical Description:	4084 - 4092
DOI:	10.1016/j.jorganchem.2007.06.009
Document Type:	Journal Article
Research Program:	Funktion und Dysfunktion des Nervensystems
Series Title:	Journal of Organometallic Chemistry 692
Subject (ZB):	J F-18-Fluoroarylation Organometallic compounds lodonium salts Fluorine-18 I -Bromo-4-[F-18]fluorobenzene
	Publikationsportal JuSER

Please use the identifier: http://dx.doi.org/10.1016/j.jorganchem.2007.06.009 in citations.

Based on the recent availability of no-carrier-added (n.c.a.) 1-bromo-4-[F-18]fluorobenzene with high radiochemical yield, the 4[F-18]fluorophenyl compounds of lithium, sodium and magnesium can now also effectively be prepared. Thus, [F-18]fluoroarene reagents with a nucleophilic reaction centre are available and suitable among others for the formation of [18F]fluorophenyl compounds with electron donating substituents in the radiosynthesis of F-18-labelled complex organic structures. For these arylation reactions, however, the presence of macroscopic amounts of a haloarene as co-reactant is necessary with all n.c.a. [F-18]fluorophenyl metallics. The F-18-fluoroarylation was verified for examples of aryl-carbon, -silicon, -sulphur, and -nitrogen bond formation with radiochemical yields of 20-25% related to the starting radioactivity of [18 F]fluoride. (c) 2007 Elsevier B.V. All rights reserved.