Description: Sleep deprivation increases A1 adenosine receptor binding in the human brain: A positron emission tomography study

This title appears in the Scientific Report : 2007

Sleep deprivation increases A1 adenosine receptor binding in the human brain: A positron emission tomography study

It is currently hypothesized that adenosine is involved in the induction of sleep after prolonged wakefulness. This effect is partially reversed by the application of caffeine, which is a nonselective blocker of adenosine receptors. Here, we report that the most abundant and highly concentrated A1 s...

Personal Name(s):	Elmenhorst, D.
	Meyer, P. T. / Winz, O. H. / Matusch, A. / Ermert, J. / Coenen, H. H. / Basheer, R. / Haas, H. L. / Zilles, K. / Bauer, A.
Contributing Institute:	Nuklearchemie; INB-4 JARA-BRAIN; JARA-BRAIN Institut für Neurowissenschaften und Biophysik - Medizin; INB-3
Published in:	The @journal of neuroscience, 27 (2007) S. 2410 - 2415
Imprint:	Washington, DC Soc. 2007
Physical Description:	2410 - 2415
DOI:	10.1523/JNEUROSCI.5066-06.2007
PubMed ID:	17329439
Document Type:	Journal Article
Research Program:	Funktion und Dysfunktion des Nervensystems
Series Title:	Journal of Neuroscience 27
Subject (ZB):	Adult Humans Male Positron-Emission Tomography Receptor, Adenosine A1: metabolism Sleep Deprivation: metabolism Sleep Deprivation: radionuclide imaging Receptor, Adenosine A1 J imaging adenosine A(1) receptor positron emission tomography [F-18]CPFPX sleep deprivation human
Link:	Get full text OpenAccess OpenAccess
	Publikationsportal JuSER

Please use the identifier: http://hdl.handle.net/2128/20514 in citations.
Please use the identifier: http://dx.doi.org/10.1523/JNEUROSCI.5066-06.2007 in citations.

It is currently hypothesized that adenosine is involved in the induction of sleep after prolonged wakefulness. This effect is partially reversed by the application of caffeine, which is a nonselective blocker of adenosine receptors. Here, we report that the most abundant and highly concentrated A1 subtype of cerebral adenosine receptors is upregulated after 24 h of sleep deprivation. We used the highly selective A1 adenosine receptor (A1AR) radioligand [18F]CPFPX ([18F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine) and quantitative positron emission tomography to assess cerebral A1ARs before and after sleep deprivation in 12 healthy volunteers and a control group (n = 10) with regular sleep. In sleep deprived subjects, we found an increase of the apparent equilibrium total distribution volume in a region-specific pattern in all examined brain regions with a maximum increase in the orbitofrontal cortex (15.3%; p = 0.014). There were no changes in the control group with regular sleep. This is the first molecular imaging study that provides in vivo evidence for an A1AR upregulation in cortical and subcortical brain regions after prolonged wakefulness, indicating that A1AR expression is contributing to the homeostatic sleep regulation.