This title appears in the Scientific Report :
2007
Please use the identifier:
http://dx.doi.org/10.1038/sj.embor.7401025 in citations.
Subunits act independently in a cyclic nucleotide-activated K+ channel
Subunits act independently in a cyclic nucleotide-activated K+ channel
Ion channels gated by cyclic nucleotides have crucial roles in neuronal excitability and signal transduction of sensory neurons. Here, we studied ligand binding of a cyclic nucleotide-activated K(+) channel from Mesorhizobium loti and its isolated cyclic nucleotide-binding domain. The channel and th...
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Personal Name(s): | Cukkemane, A. |
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Grüter, B. / Novak, K. / Gensch, T. / Bönigk, W. / Gerharz, T. / Kaupp, U. B. / Seifert, R. | |
Contributing Institute: |
Biotechnologie 1; IBT-1 Zelluläre Biophysik; INB-1 |
Published in: | EMBO reports, 8 (2007) S. 749 - 755 |
Imprint: |
London [u.a.]
Nature Publishing Group
2007
|
Physical Description: |
749 - 755 |
DOI: |
10.1038/sj.embor.7401025 |
PubMed ID: |
17668006 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
EMBO Reports
8 |
Subject (ZB): | |
Publikationsportal JuSER |
Ion channels gated by cyclic nucleotides have crucial roles in neuronal excitability and signal transduction of sensory neurons. Here, we studied ligand binding of a cyclic nucleotide-activated K(+) channel from Mesorhizobium loti and its isolated cyclic nucleotide-binding domain. The channel and the binding domain alone bind cyclic AMP with similar affinity in a non-cooperative manner. The cAMP sensitivities of binding and activation coincide. Thus, each subunit in the tetrameric channel acts independently of the others. The binding and gating properties of the bacterial channel are distinctively different from those of eukaryotic cyclic nucleotide-gated channels. |