This title appears in the Scientific Report :
2007
Please use the identifier:
http://dx.doi.org/10.1524/ract.2007.95.6.319 in citations.
Please use the identifier: http://hdl.handle.net/2128/18305 in citations.
A Nd-140/Pr-140 radionuclide generator based on physico-chemical transitions in Pr-140 complexes after electron capture decay of Nd-140-DOTA
A Nd-140/Pr-140 radionuclide generator based on physico-chemical transitions in Pr-140 complexes after electron capture decay of Nd-140-DOTA
Nd-140 was produced by irradiations of CeO2 and Pr2O3 targets leading to Ce-nat(He-3,xn)Nd-140 and Pr-141(p,2n)Nd-140 nuclear reactions. The practical yield of Nd-140 at EOB in the former reaction over the energy range of E-3He = 33.5 -> 0 MeV amounted to 3.5 MBq/mu A It and in the latter reactio...
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Personal Name(s): | Zhernosekov, K. P. |
---|---|
Filosofov, D. V. / Qaim, S. M. / Rösch, F. | |
Contributing Institute: |
Nuklearchemie; INB-4 |
Published in: | Radiochimica acta, 95 (2007) S. 319 - 327 |
Imprint: |
München
Oldenbourg
2007
|
Physical Description: |
319 - 327 |
DOI: |
10.1524/ract.2007.95.6.319 |
Document Type: |
Journal Article |
Research Program: |
Funktion und Dysfunktion des Nervensystems |
Series Title: |
Radiochimica Acta
95 |
Subject (ZB): | |
Link: |
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Publikationsportal JuSER |
Please use the identifier: http://hdl.handle.net/2128/18305 in citations.
Nd-140 was produced by irradiations of CeO2 and Pr2O3 targets leading to Ce-nat(He-3,xn)Nd-140 and Pr-141(p,2n)Nd-140 nuclear reactions. The practical yield of Nd-140 at EOB in the former reaction over the energy range of E-3He = 33.5 -> 0 MeV amounted to 3.5 MBq/mu A It and in the latter reaction over the energy range of E-p = 18.6 -> 16.2 MeV to 15.5 MBq/mu A h. These values correspond to about 41% and 60% of the respective theoretical values. Successful separations of the radionuclide were performed by means of cation-exchange chromatography resulting in decontamination factors of >= 10(8) and >= 7 x 10(5) for the cerium and praseodymium target materials, respectively. With the no-carrier-added Nd-140 obtained, an efficient Nd-140/Pr-140 radionuclide generator system was developed and evaluated. The principle of the radiochemical separation is based on physico-chemical transitions (hot-atom effects) of the daughter Pr-140 following the electron decay process of Nd-140. The parent radionuclide Nd-140(III) is quantitatively adsorbed on a solid phase matrix in the form of Nd-140-DOTA-conjugated complexes. The daughter nuclide Pr-140 is generated in an ionic species and is easily separated using low volumes of various aqueous eluents. The elution yield is at least 93% if an optimized eluent, such as DTPA solution is applied. The system remains stable at least over three half-lives of Nd-140. with high radiolytic stability and low Nd-140 breakthrough. This radionuclide generator system Nd-140 (T-1/2 = 3.37 d) provides the short-lived positron-emitting radiolanthanide Pr-140 (T-1/2 = 3.4 min) for molecular imaging using positron emission tomography (PET). |