This title appears in the Scientific Report :
2008
Please use the identifier:
http://dx.doi.org/10.1021/jp801220p in citations.
DNA Cholesteric Phases: The Role of DNA Molecular Chirality and DNA-DNA Electrostatic Interactions
DNA Cholesteric Phases: The Role of DNA Molecular Chirality and DNA-DNA Electrostatic Interactions
DNA molecules form dense liquid-crystalline twisted phases both in vivo and in vitro. How the microscopic DNA chirality is transferred into intermolecular twist in these mesophases and what is the role of chiral DNA-DNA electrostatic interactions is still not completely clear. In this paper, we firs...
Saved in:
Personal Name(s): | Cherstvy, A. G. |
---|---|
Contributing Institute: |
Theorie der Weichen Materie und Biophysik; IFF-2 |
Published in: |
The @journal of physical chemistry |
Imprint: |
Washington, DC
Soc.
2008
|
Physical Description: |
12585 - 12595 |
PubMed ID: |
18785770 |
DOI: |
10.1021/jp801220p |
Document Type: |
Journal Article |
Research Program: |
Kondensierte Materie |
Series Title: |
Journal of Physical Chemistry B
112 |
Subject (ZB): | |
Publikationsportal JuSER |
LEADER | 04147nam a2200637 a 4500 | ||
---|---|---|---|
001 | 717 | ||
005 | 20200402205407.0 | ||
856 | 7 | |u http://dx.doi.org/10.1021/jp801220p | |
909 | C | O | |o oai:juser.fz-juelich.de:717 |p VDB |
970 | |a VDB:(DE-Juel1)101364 | ||
980 | |a VDB | ||
980 | |a ConvertedRecord | ||
980 | |a journal | ||
980 | |a I:(DE-Juel1)ICS-2-20110106 | ||
980 | |a UNRESTRICTED | ||
520 | |a DNA molecules form dense liquid-crystalline twisted phases both in vivo and in vitro. How the microscopic DNA chirality is transferred into intermolecular twist in these mesophases and what is the role of chiral DNA-DNA electrostatic interactions is still not completely clear. In this paper, we first give an extended overview of experimental observations on DNA cholesteric phases and discuss the factors affecting their stability. Then, we consider the effects of steric and electrostatic interactions of grooved helical molecules on the sign of cholesteric twist. We present some theoretical results on the strength of DNA-DNA chiral electrostatic interactions, on DNA-DNA azimuthal correlations in cholesteric phases, on the value of DNA cholesteric pitch, and on the regions of existence of DNA chiral phases stabilized by electrostatic interactions. We suggest for instance that 146 bp long DNA fragments with stronger affinities for the nucleosome formation can form less chiral cholesteric phases, with a larger left-handed cholesteric pitch. Also, the value of left-handed pitch formed in assemblies of homologous DNA fragments is predicted to be smaller than that of randomly sequenced DNAs. We expect also the cholesteric assemblies of several-kbp-long DNAs to require higher external osmotic pressures for their stability than twisted phases of short nucleosomal DNA fragments at the same DNA lattice density. | ||
650 | 2 | |2 MeSH |a Animals | |
650 | 2 | |2 MeSH |a Cations: chemistry | |
650 | 2 | |2 MeSH |a DNA: chemistry | |
650 | 2 | |2 MeSH |a Horses | |
650 | 2 | |2 MeSH |a Humans | |
650 | 2 | |2 MeSH |a Models, Genetic | |
650 | 2 | |2 MeSH |a Nucleic Acid Conformation | |
650 | 2 | |2 MeSH |a Static Electricity | |
650 | 7 | |0 0 |2 NLM Chemicals |a Cations | |
650 | 7 | |0 9007-49-2 |2 NLM Chemicals |a DNA | |
650 | 7 | |2 WoSType |a J | |
915 | |0 StatID:(DE-HGF)0010 |a JCR/ISI refereed | ||
914 | 1 | |y 2008 | |
500 | |a I thank E. Grelet, D. J. Lee, A. Leforestier, F. Livolant, S. V. Malinin, A. Minsky, and J. Widom for discussions and anonymous referee for helpful comments. I acknowledge the support by the Deutsche Forschungsgemeinschaft (DFG), Grant CH 707/2-1. | ||
773 | |0 PERI:(DE-600)2006039-7 |a 10.1021/jp801220p |g Vol. 112, p. 12585 - 12595 |p 12585 - 12595 |q 112<12585 - 12595 |t The @journal of physical chemistry <Washington, DC> / B |v 112 |x 1520-6106 |y 2008 | ||
300 | |a 12585 - 12595 | ||
082 | |a 530 | ||
440 | 0 | |0 3694 |a Journal of Physical Chemistry B |v 112 |x 1520-6106 | |
588 | |a Dataset connected to Web of Science, Pubmed | ||
084 | |2 WoS |a Chemistry, Physical | ||
245 | |a DNA Cholesteric Phases: The Role of DNA Molecular Chirality and DNA-DNA Electrostatic Interactions | ||
024 | 7 | |2 pmid |a pmid:18785770 | |
024 | 7 | |2 DOI |a 10.1021/jp801220p | |
024 | 7 | |2 WOS |a WOS:000259780200005 | |
037 | |a PreJuSER-717 | ||
260 | |a Washington, DC |b Soc. |c 2008 | ||
100 | 1 | |0 P:(DE-Juel1)VDB20696 |a Cherstvy, A. G. |b 0 |u FZJ | |
041 | |a eng | ||
913 | 1 | |0 G:(DE-Juel1)FUEK414 |a DE-HGF |b Materie |k P54 |l Kondensierte Materie |v Kondensierte Materie |x 0 |z entfällt bis 2009 | |
536 | |a Kondensierte Materie |0 G:(DE-Juel1)FUEK414 |2 G:(DE-HGF) |c P54 |x 0 | ||
336 | |a ARTICLE |2 BibTeX | ||
336 | |a Nanopartikel unedler Metalle (Mg0, Al0, Gd0, Sm0) |0 0 |2 EndNote | ||
336 | |a Output Types/Journal article |2 DataCite | ||
336 | |a Journal Article |0 PUB:(DE-HGF)16 |2 PUB:(DE-HGF) | ||
336 | |a article |2 DRIVER | ||
336 | |a JOURNAL_ARTICLE |2 ORCID | ||
981 | |a I:(DE-Juel1)IBI-5-20200312 | ||
920 | |k Theorie der Weichen Materie und Biophysik; IFF-2 |0 I:(DE-Juel1)VDB782 |d 31.12.2010 |g IFF |l Theorie der Weichen Materie und Biophysik |x 0 | ||
981 | |a I:(DE-Juel1)ICS-2-20110106 | ||
990 | |a Cherstvy, A. G. |0 P:(DE-Juel1)VDB20696 |b 0 |u FZJ |