This title appears in the Scientific Report :
2016
Different binding behavior of Tau-PET tracer [F-18]-AV-1451 in AD and Tau-positive FTLD
Different binding behavior of Tau-PET tracer [F-18]-AV-1451 in AD and Tau-positive FTLD
Different binding behavior of the tau-PET tracer [F-18]-AV-1451 in Alzheimer’s disease and tau-positive frontotemporal lobar degeneration.Jochen Hammes,1 Gérard Bischof,1,2 Klaus Fliessbach,3 Kathrin Giehl,1 Frank Jessen,4 Bernd Neumaier,5 Juraj Kukolja,6 Özgür Onur,6 Alexander Drzezga,1 Thilo van E...
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Personal Name(s): | Hammes, J. (Corresponding author) |
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Bischof, Gerard Nisal / Fließbach, K. / Giehl, K. / Jessen, F. / Neumaier, Bernd / Kukolja, Juraj / Onur, Özgür / Drzezga, A. / van Eimeren, Thilo | |
Contributing Institute: |
Nuklearchemie; INM-5 Kognitive Neurowissenschaften; INM-3 |
Imprint: |
2016
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Conference: | 54. Jahrestagung der Deutschen Gesellschaft fuer Nuklearmedizin, Dresden (Germany), 2016-04-20 - 2016-04-23 |
Document Type: |
Abstract |
Research Program: |
(Dys-)function and Plasticity |
Publikationsportal JuSER |
Different binding behavior of the tau-PET tracer [F-18]-AV-1451 in Alzheimer’s disease and tau-positive frontotemporal lobar degeneration.Jochen Hammes,1 Gérard Bischof,1,2 Klaus Fliessbach,3 Kathrin Giehl,1 Frank Jessen,4 Bernd Neumaier,5 Juraj Kukolja,6 Özgür Onur,6 Alexander Drzezga,1 Thilo van Eimeren1,2,61) Multimodal Neuroimaging Group, Department of Nuclear Medicine, University of Cologne2) Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Jülich3) Department of Psychiatry and Psychotherapy, University Hospital Bonn, Bonn, Germany4) Department of Psychiatry, University Hospital Cologne, Cologne, Germany5) Institute of Radiochemistry and Experimental Molecular Imaging, University of Cologne 6) Department of Neurology, University Hospital Cologne, Cologne, GermanyAimIn Alzheimer’s disease (AD) tau accumulation primarily occurs as paired helical filaments (PHF) whereas mainly straight tau filaments (SF) are found in pure tauopathies like tau-positive frontotemporal lobar degeneration (FTLD). A recent ex vivo study showed that the tau-PET tracer [F-18]-AV-1451 has significantly higher binding to PHF in comparison to SF [Marquié Ann Neurol 2015]. Here, we systematically compare in vivo [F-18]-AV-1451 uptake in amyloid-positive/tau-positive AD cases and amyloid-negative/tau-positive FTLD cases in regions affected by neuronal dysfunction (as measured with [F-18]-FDG-PET).MethodsIn a cohort of 7 patients with worsening aphasia displaying a left temporal metabolic deficit in [F-18]-FDG-PET and clearly increased cortical uptake in [F-18]-AV-1451 tau-PET, we performed [C-11]-PiB PET to assess amyloid-positivity. We found five PiB-positive (PiB+) and two -negative (PiB-) cases. FDG and Tau-images were spatially normalized to MNI-space. We created SUV-Ratio (SUVR) images by intensity-normalization to the cerebellum and compared values for temporal regions between PiB+ and PiB- cases.ResultsAverage FDG SUVRs were comparable between PiB+ and PiB- cases in left and right temporal lobes. Regarding [F-18]-AV-1451 uptake, PiB- cases had lower temporal SUVRs than any PiB+ case. Mean SUVR over all PiB+ patients was 3.2/1.9 (maximum/average) for the left, and 3.4/1.9 for the right temporal lobe, whereas in PiB- cases SUVRs were 1.8/1.1 left, and 1.7/1.1 right. Differences between PiB+ and PiB- were highest in inferior and mid-temporal regions bilaterally.ConclusionTracer uptake of [F-18]-AV-1451 is higher in temporal regions of PiB+ forms of neurodegeneration (AD-pathology) as compared to PiB- cases, despite similar regional FDG hypometabolism. These results may represent lower amount of tau-deposition in PiB- cases, or higher binding affinity of the tracer to PHF as compared to SF-tau (tau-positive FTLD). A larger sample is needed to substantiate this finding. |